TABLE 4.

Univariate and multivariate Cox analysis of signature in TCGA dataset.

Variable	Univariate analysis		Multivariate analysis
	HR (95% CI)	p-value	HR (95% CI)	p-value
Signature	1.017 (1.014–1.020)	< 0.001	1.006 (1.001–1.010)	0.009
WHO Grade	4.794 (3,798–6,051)	< 0.001	2.332 (1.645–3.305)	< 0.001
Age	1.073 (1.061-1.084)	< 0.001	1.037 (1.021–1.054)	< 0.001
KPS	0.954 (0.944–0.965)	< 0.001	0.986 (0.973–1.000)	0.045