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. 2020 Jul 9;7:98. doi: 10.3389/fnut.2020.00098

Table 1.

List of CD-toxic proteins and potential IgE-binding food allergens identified in the five beer types using proteomics and peptidomics.

Protein name Accession
number
Organism Beer_Gluten-free Beer_Hammurabi Beer_ID331 All Barley
Malt Beer
Weissbier
Peptide matches (unique)
CD-TOXIC PROTEINS
1Bx HMW glutenin subunit Q1KL95 WHEAT (HMW)2
75k γ-secalin E5KZQ7 WHEAT (LMW)2 (LMW)1
E5KZR8 (LMW)5
E5KZS2 (LMW)5
E5KZT8 (HMW)4 (HMW)1
Avenin-3 M8ANS4 TRIUA (HMW)38 (HMW)36
Avenin-like a1 Q2A784 WHEAT (HMW)3
Avenin-like a2 P0CZ07 WHEAT (HMW)56
Avenin-like a4 D2KFH1 WHEAT (LMW)2-(PSD)2
Avenin-like a6 P0CZ10 WHEAT (PSD)2
Avenin-like a7 P0CZ11 WHEAT (HMW)1
Avenin-like b1 Q2A783 WHEAT (HMW)33
Avenin-like b2 P0CZ05 WHEAT (LMW)2-(PSD)4
Avenin-like protein G9I0U5 WHEAT (LMW)2
V5M0Y3 TRIMO (HMW)74 (HMW)55
B1-hordein P06470 HORVU (LMW)2
B3-hordein I6SJ26 HORVU (LMW)9 (LMW)9
I6SW30 (HMW)17
I6TEV5 (LMW)9
I6TMW4 (HMW)14
Q4G3S1 HORCH (HMW)11
B3-hordein (Fragment) P06471 HORVU (LMW)7-(PSD)5 (LMW)4 (HMW)25
Q4G3T9 HORCH (HMW)2
Barley (Hordeum vulgare L.) C-hordein (Fragment) Q40037 HORVU (LMW)1
Barley mRNA for B1-hordein (Fragment) Q40022 HORVU (HMW)7
B-hordein A0A0K1Z5E8 HORVV (HMW)5
I6R4A7 (LMW)3
Q0PIV6 (PSD)1 (HMW)1 (PSD)5
Q2XQF0 (HMW)1
Q3LTR1 (LMW)2 (LMW)2
C-hordein Q40055 HORVU (HMW)2 (HMW)1
Q41210 (LMW)3 (LMW)5 (LMW)9
C-hordein (Fragment) P02864 HORVS (HMW)3
P17991 (LMW)3 (PSD)2
D-hordein B0L965 HORCH (LMW)2 (LMW)1
I6SW23 HORVU (LMW)46-(PSD)47 (LMW)50
I6SW34 HORVV (LMW)40 (HMW)70
Q40054 HORVU (LMW)21 (HMW)2 (HMW)53-(LMW)9 (LMW)35 (HMW)33-(LMW)18
D-hordein (Fragment) Q02056 HORVU (LMW)3
Q40045 (HMW)11
D-type LMW glutenin
subunit (Fragment)
B6ETS0 WHEAT (HMW)11
Fast ω-gliadin A0A076G4E3 TRIMO (HMW)2
A0A0N9MGE4 (HMW)16
Gliadin R4VEK6 WHEAT (LMW)6 (HMW)17 (LMW)4
Gliadin/avenin-like seed protein D2KFG9 WHEAT (HMW)49-(LMW)1
Gliadin/avenin-like seed protein (Fragment) D2KFH2 WHEAT (HMW)18-(LMW)2
Glu-B1-1b HMW glutenin subunit Q42451 WHEAT (LMW)15
Glutenin, HMW subunit 12 P08488 WHEAT (HMW)1
Glutenin, HMW subunit DX5 P10388 WHEAT (LMW)20
Glutenin, HMW subunit DY10 P10387 WHEAT (LMW)2 (HMW)65-(LMW)36-(PSD)24
Glutenin, LMW subunit M7ZXM2 TRIUA (HMW)34
Glutenin, LMW subunit 1D1 P10386 WHEAT (PSD)20
Glutenin, LMW subunit PTDUCD1 P16315 WHEAT (LMW)2
HMW glutenin A0A0M3R6K6 TRIMO (HMW)6
K4N1X7 TRITD (LMW)6
HMW glutenin (Fragment) Q8H0L1 WHEAT (HMW)2
HMW glutenin 1Ax2.1 G0YVZ4 TRIMO (LMW)35 (HMW)37 (HMW)55
HMW glutenin protein Dx5 (Fragment) Q38LF5 WHEAT (HMW)3
HMW glutenin subunit A0A0X9BSF8 WHEAT (LMW)4
A0A1D8V7C1 (HMW)13 (HMW)9
Q6UKZ5 (LMW)1 (LMW)3
HMW glutenin subunit (Fragment) Q7XZB8 WHEAT (HMW)2
HMW glutenin subunit 1Ay A0A221HK71 TRIUA (LMW)2
HMW glutenin subunit 1Ay protein V9TN80 TRIDC (LMW)1
HMW glutenin subunit 1Ay/Ta-e3 B5TM09 TRIMO (HMW)11
HMW glutenin subunit 1By15 W0C8U3 WHEAT (LMW)5
HMW glutenin subunit 1By9 Q03871 WHEAT (HMW)7
HMW glutenin subunit 1Dy10.1 Q670Q5 WHEAT (HMW)5
HMW glutenin subunit Bx17 Q18MZ6 WHEAT (LMW)2 (LMW)7
HMW glutenin subunit x Q94IJ7 WHEAT (HMW)2
HMW glutenin subunit y Q94IJ8 WHEAT (LMW)3
HMW glutenin x-type subunit Bx7 A0A1G4P219 WHEAT (LMW)2
HMW glutenin subunit 1Dx2.2 Q599I0 WHEAT (LMW)15
HMWglutenin subunit Bx17 Q18MZ6 WHEAT (HMW)4 (HMW)63
HMWt glutenin y-type (Fragment) B8XU62 TRIMO (LMW)5
Hor1-17 C-hordein Q40053 HORVU (LMW)3 (LMW)3
HRR25-like protein A0A0L8R9P4 SACEU (LMW)1
LMW glutenin subunit D3-1 D3U326 WHEAT (HMW)25
LMW glutenin subunit group 2 type I Q8W3X5 WHEAT (LMW)2
LMW glutenin subunit LMW-H6-5-2 F6M7E1 WHEAT (LMW)8
LMW glutenin B2Y2Q7 WHEAT (LMW)32
C3VN79 (HMW)7
Q5MFK8 (HMW)8
Q5MFQ1 (LMW)2
Q7Y074 (HMW)3 (HMW)3
LMW glutenin (Fragment) A7X9Y0 TRITU (LMW)2
Q5MFN4 WHEAT (HMW)3
LMW glutenin GLU-B3 A7XDG0 TRITU (HMW)3
LMW glutenin pGL13.1 Q6QGV9 WHEAT (LMW)2
LMW glutenin storage protein P93793 WHEAT (HMW)2 (HMW)1
P93794 (PSD)2
LMW glutenin storage protein (Fragment) Q7DM83 WHEAT (HMW)3
LMW glutenin subunit A0A0A0QXD3 TRIUA (LMW)19
A4KZ73 (LMW)1
F8SGM3 (HMW)17
R4JB53 (HMW)6
R4JBL2 (HMW)26
LMW glutenin subunit (Fragment) A0A089VKL2 TRIUA (HMW)1 (LMW)3
Q9XGF0 TRITD (HMW)2
R4JB40 WHEAT (HMW)66
R4JBE8 (LMW)59
R4JBK6 (HMW)7
R4JFB5 (LMW)7
LMW glutenin subunit Glu-A3 (Fragment) Q19MN2 WHEAT (HMW)10
X2J8E3 (LMW)16 (LMW)9
LMW glutenin subunit Glu-B3 (Fragment) X2JAG4 TRITU (HMW)7
X2JC81 WHEAT (LMW)1
LMW glutenin subunit Glu-D3 R9YTM7 WHEAT (LMW)2-(PSD)2 (LMW)7
LMW glutenin subunit group 3 type II (Fragment) Q8W3W7 WHEAT (HMW)3 (HMW)2
Q8W3X4 (HMW)4
LMW glutenin subunit group 4 type II Q8W3W4 WHEAT (HMW)2
LMW glutenin subunit group 6 type IV Q8W3V6 WHEAT (HMW)14
LMW glutenin subunit LMW-B8 Q2PQJ8 TRIMO (LMW)16 (HMW)2 (HMW)3
LMW glutenin subunit LMW-Di31 Q2PQJ7 TRIDC (LMW)6 (HMW)4
LMW glutenin subunit LMW-H6-5-2 F6M7E1 WHEAT (LMW)9
LMW glutenin subunit Y22 Q38L52 TRIDC (HMW)2
LMW glutinin subunit F8SGM9 WHEAT (LMW)27
LMW protein (Fragment) C5IFV2 WHEAT (HMW)4
LMW-GS Q6SPZ1 WHEAT (HMW)3
R9XT30 (LMW)7
LMW-m glutenin subunit D0EVN9 WHEAT (LMW)8
LMW-m glutenin subunit 5 (Fragment) V9P6C5 WHEAT (HMW)2
LMW-m glutenin subunit 7 (Fragment) V9P7D1 WHEAT (LMW)4
LMW-m1 glutenin subunit A2IBJ9 TRIDC (LMW)2
Low-molecular-weightLMWsubunit Glu-A3 (Fragment) X2J8E3 WHEAT (HMW)5
Pseudo α/β-gliadin A0A0K2QJB3 WHEAT (LMW)8
A0A0K2QJX0 (HMW)35
Putative LMW glutenin subunit Q571Q5 WHEAT (LMW)7
Putative LMW glutenin subunit (Fragment) A0A0M4FLL7 TRIMO (HMW)1
Putative γ-gliadin Q571R3 WHEAT (HMW)22 (HMW)10
Putative ω-gliadin (Fragment) Q571R2 WHEAT (LMW)1
Putative ω-secalin C1KDG3 WHEAT (LMW)6
C1KFY6 (LMW)2
S-type LMW glutenin L4-55 (Fragment) Q6J160 WHEAT (LMW)1
Truncated high molecular weight glutenin 1Ay8.3 A0A168M895 TRIMO (HMW)18 (HMW)20
Truncated HMW glutenin 1Ay8.1 G0YVZ5 TRIMO (LMW)12
Type I LMW-glutenin LMW-i1 A5JJ52 TRIMO (HMW)62
X-type HMW glutenin Q0Q5D2 WHEAT (HMW)30
Y-type HMW glutenin subunit 1By M1PIT5 TRIDC (LMW)4
α/β-gliadin A0A0K2QJ85 WHEAT (PSD)1 (LMW)7
A0A0K2QJC3 (HMW)5 (HMW)9
A0A0K2QJD3 (LMW)17 (LMW)11
A0A0K2QJF4 (LMW)7 (HMW)4 (HMW)12
I0IT52 (HMW)47
P02863 (HMW)1
α/β-gliadin (Fragment) D2T2K3 WHEAT (HMW)16 (HMW)25
α/β-gliadin A-I P04721 WHEAT (LMW)2
α/β-gliadin A-II P04722 WHEAT (HMW)2
α/β-gliadin MM1 M7ZUN8 TRIUA (LMW)1
P18573 WHEAT (HMW)97-(LMW)58-(PSD)54
α/β-type gliadin Q41632 TRIUA (HMW)4-(LMW)1
α-gliadin A0A023WGC3 TRIMO (HMW)23
D2X6C9 TRITD (LMW)19
Q306G0 WHEAT (HMW)54-(PSD)6
R9XUP7 (HMW)57
X2KVH9 (LMW)37
α-gliadin (Fragment) A0A0E3UQU0 WHEAT (LMW)15
A0A0E3URD4 TRIMO (HMW)6
A0A0E3Z7F3 WHEAT (LMW)4
E7DRL1 TRIMO (HMW)4 (HMW)2
Q41533 WHEAT (HMW)19
α-gliadin Gli-1 B5U2V9 TRITI (HMW)10
α-gliadin Gli2-CN16-12 Q306F9 WHEAT (HMW)6
α-gliadin protein A0A0E3X5J7 TRIUA (HMW)1 (HMW)1
A0A0E3X5K4 TRIUA (LMW)2 (LMW)4
M4WYG5 TRIMO (HMW)21
Q2V5Z7 TRITD (LMW)4
X2KWL1 WHEAT (HMW)13
α-gliadin storage protein Q41529 WHEAT (HMW)4
α-gliadin storage protein (Fragment) Q2QL58 TRIMO (HMW)1
α-type gliadin (Fragment) Q3YFI0 TRIDC (LMW)1
γ-2-gliadin P25-27 Q7M1M5 TRITU (HMW)3
γ-gliadin B5ANT0 WHEAT (LMW)18
B6DQB8 (LMW)2 (LMW)2
B6UKM9 (LMW)21
B6UKS0 TRIUA (HMW)13 (HMW)23
B8XU47 TRIMO (HMW)74
R9XV71 WHEAT (HMW)72
U5UA54 (LMW)21
γ-gliadin (Fragment) B6DQB1 WHEAT (LMW)10
B8XU49 TRIMO (LMW)2 (HMW)32
B8XU49 (LMW)5
Q1W676 WHEAT (HMW)1
γ-gliadin 9 M9TLK0 WHEAT (HMW)11 (HMW)3
γ-gliadin B P06659 WHEAT (PSD)25
γ-hordein-1 P17990 HORVU (HMW)6-(PSD)1 (HMW)9
γ-hordein-3 P80198 HORVU (HMW)11-(LMW)3 (HMW)1-(LMW)7-(PSD)6 (HMW)28 (HMW)50-(LMW)6 (HMW)26-(LMW)2-(PSD)2
ω-5 gliadin Q402I5 WHEAT (LMW)10
ω-gliadin A0A0B5JD20 WHEAT (HMW)10
D2KKB1 TRITU (LMW)2
Q0GK30 TRITI (LMW)40
U5U6L8 WHEAT (LMW)4
ω-gliadin (Fragment) C0KEI1 WHEAT (HMW)2 (HMW)2
C0KEI2 (LMW)5
D6QY47 TRIMO (LMW)12 (HMW)2 (HMW)4 (LMW)3
ω-gliadin protein A0A0E3SZN6 TRIUA (LMW)5
ω-secalin A0A159KI54 WHEAT (HMW)1 (HMW)9
C4NFQ1 (LMW)17
IGE FOOD ALLERGENS
7 kDa lipid transfer protein O81135 HORVU (HMW)1
Barley trypsin inhibitor CMc (Fragment) E7BB45 HORVV (HMW)4
Bowman-Birk type trypsin inhibitor M0Y075 HORVV (HMW)1
P81713 WHEAT (HMW)2
Chymotrypsin inhibitor WCI P83207 WHEAT (HMW)4
CMd subunit of tetrameric α-amylase inhibitor O23982 HORVU (PSD)1
Dimeric α-amylase inhibitor C3VW72 TRIDC (HMW)2
C3VWA4 (HMW)6
C3VWG2 (HMW)24
Dimeric α-amylase inhibitor (Fragment) A4GFP2 TRIDC (HMW)8
A4GFQ9 (HMW)2
M1PST7 TRIUA (HMW)1
Endogenous α-amylase/subtilisin inhibitor P16347 WHEAT (HMW)3 (HMW)3 (HMW)10-(LMW)11
P16347 (PSD)13
Monomeric α-amylase inhibitor C4P622 TRIDC (HMW)18
Non-specific lipid-transfer protein A0A1D5RXY7 WHEAT (HMW)2 (HMW)1
A0A1D5YFR5 (HMW)12 (HMW)18
Q5UNP2 HORVV (HMW)3 (HMW)12 (HMW)6
T1MH09 TRIUA (LMW)1
Non-specific lipid-transfer protein (Fragment) P24296 WHEAT (HMW)3 (HMW)3 (LMW)3-(PSD)2
Non-specific lipid-transfer protein 1 P07597 HORVU (HMW)31-(LMW)3-(PSD)4 (HMW)12-(LMW)4-(PSD)3 (HMW)47-(LMW)4 (HMW)57-(LMW)4 (HMW)34-(LMW)3
Nonspecific lipid-transfer protein 2, putative, expressed Q337E3 ORYSJ (HMW)2 (HMW)2
Non-specific lipid-transfer protein 2G M7YYL5 TRIUA (HMW)3
P82900 WHEAT (HMW)7 (HMW)15
Non-specific lipid-transfer protein 2P P82901 WHEAT (HMW)21 (HMW)6 (HMW)14
Non-specific lipid-transfer protein 4.3 Q42842 HORVU (HMW)2
Oleosin F2E8X4 HORVV (PSD)1 (HMW)1 (HMW)4
I3NM41 WHEAT (HMW)3-(LMW)5
Q43769 HORVU (LMW)7 (LMW)5 (HMW)3
Q43770 (HMW)1 (LMW)2-(PSD)2 (HMW)2 (HMW)1
Oleosin (Fragment) Q43474 HORVU (LMW)1 (HMW)2
Probable non-specific lipid-transfer protein P20145 HORVU (HMW)22 (HMW)8 (HMW)26 (HMW)27 (HMW)14
Probable secreted beta-glucosidase SIM1 P40472 YEAST (HMW)4
Serpin 3 C0LF32 WHEAT (HMW)46
Serpin-Z1B P93693 WHEAT (HMW)1 (HMW)1 (LMW)5
Serpin-Z1C M7ZQF1 TRIUA (HMW)27
Serpin-Z2B P93692 WHEAT (LMW)2
Serpin-Z4 M0UEE6 HORVV (HMW)22 (HMW)73 (HMW)65-(LMW)3 (HMW)44
P06293 HORVU (LMW)2-(PSD)2 (HMW)30-(LMW)3-(PSD)3 (LMW)2
Serpin-Z7 M8A993 TRIUA (HMW)1 (HMW)4
Q43492 HORVU (LMW)1-(PSD)1
Starch synthase, chloroplastic/amyloplastic Q8H1Y7 HORVV (HMW)2
Subtilisin-chymotrypsin inhibitor CI-1A P16062 HORVU (HMW)3 (HMW)4 (HMW)3
Subtilisin-chymotrypsin inhibitor CI-1B P16063 HORVU (PSD)1
Subtilisin-chymotrypsin inhibitor-2A P01053 HORVU (HMW)1
Trypsin inhibitor C5J3R4 TRIMO (HMW)19 (HMW)9 (HMW)1
Trypsin inhibitor CMc P34951 HORVU (LMW)2
Trypsin inhibitor CMe M0UY52 HORVV (HMW)13
Trypsin inhibitor Cme P01086 HORVU (HMW)5 (HMW)3 (HMW)15 (HMW)19
Z-like serpin (Fragment) Q9S8N4 WHEAT (HMW)5 (HMW)6
α/β-amylase Q84T20 HORVV (HMW)32
α-amylase inhibitor (Fragment) Q7M219 TRITD (HMW)2
α-amylase inhibitor 0.19 P01085 WHEAT (HMW)40
α-amylase inhibitor 0.28 P01083 WHEAT (HMW)2 (LMW)3-(PSD)5
α-amylase inhibitor 0.53 P01084 WHEAT (LMW)1
α-amylase inhibitor BDAI-1 P13691 HORVU (HMW)11 (HMW)13 (HMW)30 (HMW)28 (HMW)20
α-amylase inhibitor BMAI-1 (Fragment) P16968 HORVU (HMW)2 (HMW)2 (HMW)10 (HMW)4
α-amylase type A isozyme P00693 HORVU (HMW)1
α-amylase type B isozyme P04063 HORVU (PSD)1 (LMW)1 (HMW)4
α-amylase/subtilisin inhibitor P07596 HORVU (HMW)1-(LMW)2-(PSD)1 (LMW)8-(PSD)8 (HMW)4-(LMW)1 (HMW)6-(LMW)9 (HMW)2-(LMW)2
α-amylase/trypsin inhibitor P16969 HORVU (HMW)1
α-amylase/trypsin inhibitor CM1 P16850 WHEAT (HMW)2
α-amylase/trypsin inhibitor CM16 P16159 WHEAT (HMW)4 (HMW)18
α-amylase/trypsin inhibitor CM2 P16851 WHEAT (HMW)30
α-amylase/trypsin inhibitor CM3 P17314 WHEAT (HMW)2
α-amylase/trypsin inhibitor Cma P28041 HORVU (HMW)5 (HMW)4 (HMW)18 (HMW)27
α-amylase/trypsin inhibitor CMb P32936 HORVU (HMW)7 (HMW)19 (HMW)18
α-amylase/trypsin inhibitor CMd M0Y227 HORVV (HMW)19
P11643 HORVU (HMW)4 (HMW)14 (HMW)33
β-amylase A0A1D5YFA7 WHEAT (HMW)4
P16098 HORVU (HMW)4-(LMW)6-(PSD)1 (HMW)2 (HMW)14 (LMW)10
P82993 HORVS (LMW)4 (LMW)6-(PSD)6 (LMW)2 (LMW)3-(PSD)3
W5EKI0 WHEAT (LMW)3 (LMW)1 (PSD)1 (HMW)8-(LMW)4
β-amylase (Fragment) Q7X9M2 WHEAT (HMW)2
Q9SB23 HORVU (HMW)1

HMW and LMW indicate if proteins were detected in the high- or low-molecular weight fractions, respectively, along with the number of unique peptides identified. PSD indicates the peptides belonging to a protein entry detected “post simulated digestion.”