Table 3.

Major adverse events and postnatal complications

	Therapeutic hypothermia (n=25)	Standard care (n=25)	P value
Major adverse events
Death or withdrawal of care during intervention	2 (8)	1 (4)	0.55
Major cardiac arrhythmia	0	0	–
Persistent hypotension	0	0	–
Prolonged coagulation time	23 (92)	19 (76)	0.12
Thrombocytopenia	4 (16)	2 (8)	0.38
Severe haemorrhage	0	2 (8)*	0.15
PPHN	0	0	–
Culture-positive sepsis	0	0	–
Postnatal complications
Death or withdrawal of care after intervention	0	4 (17)†	0.04
Clinical seizures	20 (80)	22 (88)	0.44
≥2 anticonvulsants	9 (36)	12 (48)	0.39
Mechanical ventilation >24 hours	2 (8)	6 (24)	0.12
Inotropic support	14 (56)	17 (68)	0.38
Treated coagulopathy	10 (40)	8 (32)	0.56
Hypoglycaemia	2 (8)	1 (4)	0.55
Hyperglycaemia requiring insulin	1 (4)	1 (4)	–

Data are n (%).

*Both were subgaleal bleed requiring packed cell transfusion.

†Denominator 24 due to one withdrawal of care during the intervention.

PPHN, persistent pulmonary hypertension of the newborn.