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. 2020 Jul 9;7:331. doi: 10.3389/fmed.2020.00331

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Copyright © 2020 Saponaro, Sestito, Runfola, Rapposelli and Chiellini.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A structure-based representation of TRβ-selective thyromimetics. (A) AryloxyPhenyl based thyromimetics include: Resmetirom (MGL-3196) and Eprotirome (KB2115). (B) Diphenylmethane based thyromimetics include: Sobetirome (GC1), Sob-AM2, VK2809 (MB08711), MB07344, and novel IS25 and TG68.