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. 2020 Jul 15;3:380. doi: 10.1038/s42003-020-1109-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a–h Antiviral effects of digoxin and ouabain against two ZIKV strains in different cell lines. The cell culture supernatants were subjected to a viral titer assay (a, c, e–h), whereas the cell lysates were assessed by qRT-PCR (b, d), and duplicate cells were analyzed for protein expression by immunofluorescence staining assay (IFA) (i, j). IFA images showing the viral protein (green) and nuclei (blue) in Vero cells. k Dose–response curves of ouabain and digoxin for inhibition of ZIKV infection in Vero cells. Data are represented as the means ± SDs from at least three independent experiments. ****P < 0.0001, ***P < 0.001, **P < 0.01, *P < 0.05.