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. 2020 Jul 15;10:11669. doi: 10.1038/s41598-020-68355-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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B-factor analysis and comparison of the ligand electron density maps. (A) B-factor analysis for 5HT_1B/ERG/SRP2070Fab (left) and 5HT_1B/ERG (PDB ID: 4IAR) (right). Both the overall structure and the area around ligand are shown. (B) B-factor analysis for AT₂R-BRIL/s-Ang II/SRP2070Fab (left) and AT₂R/s-Ang II (PDB ID: 5XJM) (right). Both the overall structure and the area around ligand are shown. (C) The ligand electron density map of AT₂R-BRIL/s-Ang II/SRP2070Fab (left) and AT₂R/s-AngII (PDB ID: 5XJM) (right). The omitted mFo–DFc electron density map contoured at 3.0 σ (Polder map).