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. 2020 Jul 15;11:3548. doi: 10.1038/s41467-020-17178-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Using unsupervised hierarchical clustering, the symptomatic CMV biosignature (2592 transcripts) applied to the entire cohort of infants with CMV (n = 80) and 10 healthy controls, yielded a mixed distribution that did not reliably distinguish symptomatic from asymptomatic cCMV infection. b Following the same strategy, the asymptomatic CMV biosignature (3324 transcripts) was applied to the entire cohort of infants utilizing unsupervised hierarchical clustering and also yielded a mixed distribution that did not reliably distinguish asymptomatic from symptomatic cCMV-infected infants. Transcripts are organized in a heatmap format where each row represents a transcript and each column represents a patient sample. Red color indicates overexpression and blue color underexpression of a transcript compared with the median expression of healthy controls (yellow). Clusters for healthy controls are depicted in blue, for infants with symptomatic cCMV infection in red and asymptomatic cCMV infection in green.