Fig. 3. Modular expression in symptomatic and asymptomatic cCMV infection.

Modules (M) are groups of genes that are co-expressed and shared a similar biological function. Sixteen selected modules pertaining to innate and adaptive immune responses are represented above and included three related to interferon, one to monocytes, one to neutrophils, six to inflammation, two T cell related, one related to cytotoxic/NK cells, one plasma cell, and one B-cell related. The intensity of the modules (dots) indicate the proportion of overexpressed (in red) or underexpressed (in blue) transcripts within each module. Numeric values indicate the percentage of transcripts expressed in each specific module compared with healthy controls. Blank dots indicate that <10% of the genes in the module were differentially expressed compared with controls. The panel on the left includes innate immunity-related modules, and the panel in the right is comprised of adaptive immunity modules. Sx symptomatic, Asx asymptomatic.