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. 2020 Jul 15;11:3548. doi: 10.1038/s41467-020-17178-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Mean percent difference* in modular expression of innate (inflammation, neutrophil, monocytes, interferon) and adaptive immunity (T cell and B cell/plasma cell) modules are plotted and compared over time (baseline, 1 year, 2 years, and 3 years of age) for infants with symptomatic (orange square) and asymptomatic (green diamond) congenital CMV infection. *The mean percent difference was calculated by the percentage of genes upregulated (positive percent) minus the percentage of downregulated genes (negative percent) within each module. When the biological functions were represented by more than one module (i.e., interferon, inflammation, T cells, see Fig. 3), modular mean was derived and the percentage difference calculated as explained above.