Table 2.
Hazard ratios and 95% confidence intervals for the incidence of end-stage renal disease by quartiles of baseline gamma-glutamyl transferase and average successive variability of gamma-glutamyl transferase.
| Events (n) | Follow-up duration (person-years) | Incidence rate (per 1,000 person-years) | Model 1 | Model 2 | Model 3 | |
|---|---|---|---|---|---|---|
| Baseline GGT quartilesa | ||||||
| Q1 (n = 1,593,642) | 3,254 | 10,166,664.8 | 0.32 | 1(Ref.) | 1(Ref.) | 1 (Ref.) |
| Q2 (n = 1,429,570) | 2,726 | 9,141,060.0 | 0.30 | 0.95 (0.90–1.00) | 0.86 (0.82–0.91) | 1.06 (1.00–1.11) |
| Q3 (n = 1,519,057) | 3,029 | 9,716,606.0 | 0.31 | 0.99 (0.94–1.04) | 0.81 (0.77–0.85) | 1.11 (1.06–1.17) |
| Q4 (n = 1,516,726) | 3,048 | 9,638,948.5 | 0.32 | 1.08 (1.03–1.14) | 0.76 (0.72–0.80) | 1.15 (1.09–1.21) |
| P for trend | < 0.001 | < 0.001 | < 0.001 | |||
| GGT ASV quartilesb | ||||||
| Q1 (n = 1,515,267) | 2,405 | 9,645,912.3 | 0.25 | 1(Ref.) | 1(Ref.) | 1 (Ref.) |
| Q2 (n = 1,514,102) | 2,649 | 9,732,995.2 | 0.27 | 1.08 (1.02–1.14) | 1.03 (0.97–1.09) | 1.01 (0.95–1.07) |
| Q3 (n = 1,514,878) | 3,043 | 9,705,782.5 | 0.31 | 1.23 (1.17–1.30) | 1.09 (1.04–1.15) | 1.06 (1.01–1.12) |
| Q4 (n = 1,514,748) | 3,960 | 9,578,589.3 | 0.41 | 1.59 (1.52–1.68) | 1.27 (1.21–1.34) | 1.12 (1.06–1.18) |
| P for trend | < 0.001 | < 0.001 | < 0.001 | |||
GGT, gamma-glutamyl transferase; ASV, average successive variability.
aQ1: 4–22 (men), 4–14 (women) U/L; Q2: 23–31(men), 15–18 (women) U/L; Q3: 32–50 (men), 19–25 (women) U/L; Q4: 51–1,000 (men), 26–1,000 (women) U/L.
bQ1: 1–1.16 (men), 1–1.15 (women) U/L; Q2: 1.16–1.27 (men), 1.15–1.26 (women) U/L; Q3: 1.27–1.45 (men), 1.26–1.45 (women) U/L; Q4: 1.45–79.47 (men), 1.45–76.59 (women) U/L. Model 1 is adjusted for age, sex, baseline estimated glomerular filtration rate and body mass index. Model 2 is the same as model 1 plus adjustments for moderate drinking, current smoking, regular exercise, and presence of diabetes, hypertension, and dyslipidemia. Model 3 is the same as model 2 plus adjustments for hemoglobin and an income in the lowest 20%. Additionally, baseline GGT was adjusted in the GGT ASV quartiles.