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VEGFA/VEGFR2 regulates edema and tissue damage in myocardial infarction. Activation of VEGFR2 on endothelial cells leads to phosphorylation on Y949 and subsequently, phosphorylation of VE-cadherin on Y685, leading to dismantling of adherens junctions and leakage, edema, neutrophil infiltration, MPO release, and tissue damage. Mutation of Y949 in VEGFR2 halts edema and improves survival after myocardial infarction.
