Table 1.

Summary of SDDSs based on 2D nanomaterials.

2D materials	modification of 2D materials	Response	clinical application	Biological model	Ref
BP	Polymer	Light	anticancer	4T1 tumor	[127]
MoS2	Polymer	Light &pH	antitumor	HT29 tumor	[128]
GO	Ag	N.A.	antibacterial	antibacterial	[137]
GO	N.A.	N.A.	anticancer	anticancer	[138]
MoS2	Liposomes	Light	antitumor	4T1	[139]
GO	Polymer	pH	antitumor	Hela cells	[125]
BP	Polymer	Light	anticancer	MCF7 breast tumor	[165]
MnO2	Aptamer	Magnetic field	antitumor	N.A.
MnO2	glucose oxidase	Light &Magnetic field	antitumor	A375 tumor
GO	Hydrogel	Magnetic field	antitumor	S180 tumor	[140]
GO	Hydrogels	N.A.	antitumor	antitumor	[141]
GO	Liposomes	Light	N.A.	N.A.	[143]
graphene	Liposomes	Light	anticancer	MCF-7 cells	[144]
WS2/MoS2	Liposomes	N.A.	anticancer	HeLa cells	[145]
GO	Films	pH	the control of coating techniques	N.A.	[147]
GO	BNN6	Light	anticancer	143B cells	[152]
BP	Polymer	Light	intelligent implantable devices	N.A.	[153]
BP	Pt	Light	antitumor	4T1	[154]
BP	Hydrogels	Light	postoperative treatment of cancer	HeLa	[155]
GO	Polymer	pH	anticancer	Hela and L929 cells	[159]
GO	Polymer	pH	antitumor	HeLa cells	[160]
GO	Polymer	pH	anticancer	SMMC-7721 cells	[161]
GO	Hydrogels	Light &pH	anticancer	HeLa cells	[162]
GO	Polymer	redox	antitumor	B16 tumor	[169]
rGO	Polymer	Light	anticancer	4T1 tumor	[170]
rGO	gold and folic acid	Light &pH	anticancer	MCF-7 cells	[171]
BP	Hydrogels	Light	anticancer	SMMC-7721 cells	[172]
MoS2	Polymer	N.A.	antibacterial	S. aureus	[174]
GO	Polymer	N.A.	antibacterial	S. aureus and E. coli	[175]
graphene	Cu2O	N.A.	antibacterial	Vibrio cholerae and Salmonella typhimurium	[176]
BP	Liposomes	Light	antibacterial	Methicillin-resistant Staphylococcus aureus	[177]
GO	N.A.	N.A.	anti-Alzheimer's disease	N.A.	[180]
graphene	N.A.	N.A.	antiparkinsonian	N.A.	[181]
GO	Polymer	N.A.	antiparkinsonian	N.A.	[182]
GO	Hydrogels	thermosensitive	bone tissue repair	Human MG-63 cells	[183]
graphene	Polymer	N.A.	bone tissue repair	SaOS-2 cell	[184]
GO	Films	N.A.	bone tissue repair	Defective skulls of Sprague Dawley rats	[185]
MoS2	Films	N.A.	bone tissue repair	rat bone marrow mesenchymal stem cells	[186]
GO	N.A.	N.A.	diabetes	NIT-1 cells	[188]
GO	Polymer	N.A.	diabetes	N.A.	[189]
GO	Polymer	N.A.	diabetes	INS-1 cells	[190]
graphene	Gold	temperature	diabetes	N.A.	[191]
BP	Polymer	Light	anticancer	Hela tumor	[200]
graphene	Antibody	pH	anticancer	MDA-MB-231 cell	[201]
GO	Hydrogels	Light/redox	anticancer	HeLa cells	[202]
graphene	N.A.	N.A.	respiratory diseases	BEAS-2B cells	[205]
GO	Polymer	pH	anticancer	Hela and L929 cells	[206]