Table 1.
Characteristics of patients with and without early neurological deterioration.
| Early neurological deterioration |
|||
|---|---|---|---|
| With |
Without |
p |
|
| (n = 11) | (n = 59) | ||
| Background characteristics | |||
| Male, n (%) | 6 (54.6) | 41 (69.5) | 0.4853 |
| Age, years, mean (SD) | 75.1 (14.6) | 71.9 (12.5) | 0.4576 |
| History of | |||
| Ischemic stroke, n (%) | 2 (18.2) | 7 (11.9) | 0.6249 |
| Ischemic heart disease, n (%) | 0 (0.0) | 8 (13.6) | 0.3400 |
| Hypertension, n (%) | 9 (81.8) | 39 (66.1) | 0.4825 |
| Diabetes mellitus, n (%) | 5 (45.5) | 20 (33.9) | 0.5056 |
| Dyslipidemia, n (%) | 5 (45.5) | 23 (39.0) | 0.7447 |
| Current smoking, n (%) | 2 (18.2) | 18 (30.5) | 0.4935 |
| Premorbid | |||
| Antiplatelet agents, n (%) | 2 (18.2) | 13 (22.0) | 1.0000 |
| Antihypertensive agents, n (%) | 7 (63.6) | 33 (55.9) | 0.7472 |
| Hypoglycemic agents, n (%) | 5 (45.5) | 14 (23.7) | 0.1548 |
| Statin, n (%) | 4 (36.4) | 14 (23.7) | 0.4561 |
| NIHSS, median (IQR) | 3 (2–6) | 3 (1–5) | 0.6950 |
| SBP on admission, mmHg, mean (SD) | 171.6 (33.9) | 164.1 (28.7) | 0.4421 |
| DBP on admission, mmHg, mean (SD) | 88.5 (20.1) | 87.8 (15.5) | 0.8837 |
| Blood test findings, median (IQR) | |||
| Hematocrit, % | 41.4 (36.1–42.8) | 41.2 (38.3–43.9) | 0.3492 |
| Aspartate aminotransferase, U/L | 19 (14–23) | 18 (16–23) | 0.9161 |
| Alanine aminotransferase, U/L | 12 (8–36) | 15 (10−21) | 0.6567 |
| γ-glutamyl transpeptidase, U/L | 29 (17–45) | 24.5 (17–33) | 0.7605 |
| Lactate dehydrogenase, U/L | 194 (180–256) | 192 (168–210) | 0.2867 |
| Alkaline phosphatase, U/L | 296 (233–338) | 216 (187–262) | 0.0081 |
| eGFR | 70.2 (58.8–78.7) | 62.6 (53.3–70.6) | 0.1175 |
| LDL-cholesterol, mg/dL | 103 (88–134) | 125 (93–145) | 0.2485 |
| HDL-cholesterol, mg/dL | 42 (38–54) | 42 (37–54) | 0.8844 |
| Triglyceride, mg/dL | 122 (56–165) | 117 (80.5–211) | 0.4790 |
| Glucose, mg/dL | 136 (117–158) | 124 (104–163) | 0.3492 |
| Hemoglobin A1c, % | 6.25 (5.775–7.425) | 6.05 (5.7–6.625) | 0.4364 |
| CRP, mg/dL | 0.37 (0.08–2.24) | 0.18 (0.06–0.34) | 0.1011 |
| D-dimer, ng/mL | 1 (0.7–3.6) | 0.8 (0.6–1.2) | 0.2131 |
SD indicates standard deviation; IQR, interquartile range; SBP, systolic blood pressure; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; LDL, low-density lipoprotein; HDL, high-density lipoprotein; CRP, C-reactive protein.