Fig. 7.
Schematic overview of the crucial roles of miR-122-5p in rat aortic adventitial fibroblasts. MiR-122-5p serves as an important regulator of ATII-mediated loss of autophagy and promotion of apoptosis, oxidative stress, and inflammation in rat adventitial fibroblasts by modulating the SIRT6-Elabela-ACE2 signaling. ACE2, angiotensin-converting enzyme 2; ATII, angiotensin II; ELA, elabela; IL, interleukin; SIRT6, sirtuin 6.