TABLE 1.
E6 and E7 from beta-3 HPV differentially affect cell growth ability when retrotransduced in primary keratinocytesa
| Retrovirus | Outcome to date |
||
|---|---|---|---|
| Donor 1 | Donor 2 | Donor 3 | |
| pLXSNØ | Dead at 1 PD | Dead at 1 PD | Dead at 1 PD |
| HPV49 | 108 PD | 54 PD | 5 PD |
| HPV75 | 63.5 PD | 50.5 PD | ND |
| HPV76 | 101 PD | 49.5 PD | 6 PD |
| HPV115 | Dead at 7.5 PD | Dead at 1 PD | Dead at 1 PD |
a
Data represent the number of population doublings (PDs) reached to date by the indicated keratinocytes (from 3 different donors) stably expressing E6 and E7 of beta-3 HPVs or carrying the empty retroviral vector (pLXSNØ). ND, not done.