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. 2020 Jul 15;5(4):e00482-20. doi: 10.1128/mSphere.00482-20

TABLE 1.

Linear epitopes mapped to hantavirus glycoproteins from previously isolated monoclonal antibodies or human sera from convalescent survivors of infection

Species Method Target MAb/serum Neutralizing activity? Residues Amino acid sequence Reference(s)
PUUV (strain Sotkamo) Phage display peptide library Gn 5A2 Yes 61–72, 264–280 SLKLESSCNFDL, EPLYVPTLDDYRSAEVL 33, 34
Gc 1C9 Yes 822–834 EQTCKTVDSNDCL
Gc 4G2 Yes 904–921 KCAFATTPVCQFDGNTIS
PUUV (strain Sotkamo) Phage display peptide library Gn Human serum Not tested 22–30 VNAKNLNEL 34
Gn Not tested 61–72 SLKLESSCNFDL
Gn Not tested 82–96 FTKWTWETKGDLAEN
Gn Not tested 442–453 TVYCNGVKKVIL
Gc Not tested 946–966 SALEWIDLDSSLRDHINVIVS
SNV (isolate 3H226) Western blotting of truncated proteins Gn Human serum Not tested 59–89 LKIESSCNFDLHVPATTTQKYNQVDWTKKSS 36
HTNV (strain 76-118) Peptide scan Gc M7, Y1, Y5, Y7, Y22 Yes 916–924, 954–963 KVMATIDSF, LVTKDIDFD 40
ANDV (strain CHI-7913) Peptide scan Gn Human serum Yes 14–26 TLTLAMPKTTYEL 32
Peptide scan Gc Yes 955–967 NLVLNRDVSFQDL
Peptide scan Gc Yes 691–703 RKLTNPANKEES