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Data from various studies comparing the frequency of recurrent somatic gene mutations in multiple myeloma
| Gene Mutation Frequency (%) | |||
|---|---|---|---|
|
| |||
| Gene | Lohr et al 2014 [91] (n = 203) | Bolli et al 2014 [89] (n = 67) | Walker et al 2015 [96] (n = 463) (NCT01554852) |
| KRAS | 23 | 20 | 21 |
| NRAS | 20 | 20 | 19 |
| FAM46C | 11 | 10 | 6 |
| BRAF | 6 | 12 | 7 |
| TP53 | 8 | 12 | 3 |
| DIS3 | 11 | 1 | 9 |
| SP140 | 4 | 6 | - |
| EGR1 | 4 | 6 | 4 |
| TRAF3 | 5 | 2 | 4 |
| ATM | 4 | 3 | 3 |
| CCND1 | 3 | 4 | 2 |
| LTB | 1 | 4 | 3 |
| IRF4 | 2 | - | 3 |
| FGFR3 | 2 | - | 3 |
