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In-loop radiosynthesis of D-[11C]Met. The approach we previously employed used a D-homocysteine thiolactone precursor whose alkylation conditions rendered the compound susceptible to racemization. Here a non-cyclic chiral precursor was employed. (A) Radiosynthesis of D-[11C]Met from D-homocysteine. (B) Characterization of D-[11C]Met by HPLC. A sample of L-Met was analyzed separately (see supplementary information) and confirmed > 99% ee for the desired D-enantiomer.
