Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jun 15;26(3):261–279. doi: 10.3350/cmh.2020.0032

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 by The Korean Association for the Study of the Liver

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 1. — The relationship between chronic HBV infection and liver disease progression. The figure shows the clinical stages involved in the natural history of CHB. The serum biomarkers HBcrAg and M2BPGi provide valuable predictive data for the effective management of CHB. It is important to monitor patients at high risk and to treat them early to prevent liver complications, cirrhosis, and HCC development. AFP, PIVKA-II, and AFP-L3 are HCCspecific tumor markers summarized in this review. HBV, hepatitis B virus; HCC, hepatocellular carcinoma; TACE, transcatheter arterial chemoembolization; TKIs, tyrosine kinase inhibitors; AFP, alpha fetoprotein; PIVKA-II, protein induced by vitamin K absence or antagonist-II; AFP-L3, Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein; DKK-1, Dickkopf-1; HBcrAg, hepatitis B core-related antigen; M2BPGi, Mac-2 binding protein glycan isomer; HBsAg, hepatitis B surface antigen.