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Changes in liver biopsy indications over time. Liver biopsies for viral hepatitis and malignancy decreased; whereas liver biopsies for non-alcoholic fatty liver disease, drug-induced liver disease, alcohol, and autoimmune hepatitis increased. LC, liver cirrhosis; PBC, primary biliary cholangitis; NAFLD, non-alcoholic fatty liver disease; HCV, hepatitis C virus; HBV, hepatitis B virus.
