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. Author manuscript; available in PMC: 2020 Jul 16.
Published in final edited form as: Mutat Res. 2011 Mar 3;714(1-2):1–10. doi: 10.1016/j.mrfmmm.2011.02.006

Fig. 6.

Fig. 6.

Development of spontaneous tumors in mice with wildtype and mutant Plk3. (A) Wildtype mice and mice heterozygous and homozygous for Plk3 were maintained for 24 months and monitored for palpable tumors twice a week. Mice were killed when tumors reached 1.0 cm in diameter or when mice appeared to be in distress or were found dead. In all cases, necropsy with histology of representative organs was performed, and tumors and tumor types were noted. (B) Comparison by gender of mice of each genotype that had developed spontaneous tumors by 24 months of age. (C) Comparison by gender (upper panel) or regardless of gender (lower panel) of mice of each genotype that had developed spontaneous tumors by 24 months of age.