Table 1. Baseline characteristics and comparison of results.
Author /Year | Cheng Y, et al. (2020) | Chen T, et al. (2020) | Gandolfini I, et al. (2020) | Wang L, et al. (2020) | Zhang H, et al. (2020) | Total |
Study location | China | China | Italy | China | China | |
Number of patients | 701 | 274 | 2 | 116 | 5 | 1098 |
M | 367 (52%) | 171 (62%) | 1 (50%) | 67 (58%) | 4 (80%) | 610 (55%) |
F | 334 (48%) | 103 (38%) | 1 (50%) | 49 (42%) | 1 (20%) | 488 (45%) |
Median age (Yr) | 63 | 62 | 64 | 54 | 45 | |
Patients with known CKD or TRx | 14 (2%) | 4 (1%) | 2 (100%) | 5 (4%) | 5 (100%) | 30 (3%) |
Patients with AKI after COVID-19 infection | 36 (5%) | 29 (10%) | 1 (50%) | 0 (0%) | 0 (0%) | 66 (6%) |
On admission: BUN/Cr (mg/dL) (mean) | - | 13.72 / 0.86 | - / 2.3 | With CKD: 89.83±24.03 / 10.62±1.34 Without CKD: 14.65±4.82 / 0.88±0.29 | 33.27±20.08 / 2.10±1.44 | |
Change in BUN/Cr (mg/dL) (mean) | - | 23.52 / 0.99 | - / 2.8 | With CKD: 89.44±25.71 / 10.34±1.85 Without CKD: 14.53±5.80 / 0.82±0.28 | - | |
Change in eGFR (mL/min) (mean) | - | - | - | With CKD: 14.43±7.34 to 22.86±9.37 Without CKD: 129.81±10.33 to 127.96±9.65 | - | |
Mortality with AKI | 34 (94%) | 28 (96%) | 0 (0%) | 0 (0%) | 0 (0%) | 62 (94%) |
Mortality without AKI | 79 (12%) | 85 (35%) | 1 (100%) | 7 (6%) | 0 (0%) | 172 (17%) |
Major treatment provided (including mechanical ventilation) | Arbidol, interferon, lopinavir and ritonavir, glucocorticoids, antibiotics | Antivirals, glucocorticoids, IVIGs, antibiotics, interferon | Hydroxychloroquine, lopinavir + ritonavir, or darunavir + cobicistat, colchicine | - | Antiviral (oseltamivir or arbidol), antibacterial therapy (cefixime), IVIGs, triple immunosuppression with glucocorticoids, mycophenolate mofetil and calcineurin inhibitors |