Table 2. Peptides Binding Selectively to One Eph Receptora.
| target | peptide | IC50 peptide | IC50 cells | developed by | radiolabeling for imaging |
|---|---|---|---|---|---|
| EphA2 | YSAYPDDSVPMMS | 1 μM (agonist) | Koolpe 2002 (Pasquale group) | ||
| EphA2 | SWLAYPGAVSYR | 1 μM (agonist) | Koolpe 2002 (Pasquale group) | Pretze 201415 (Pietzsch group) | |
| Liu 201416 (An group) | |||||
| EphA4 | KYLPYWPVLSSL | 1 μM (antagonist) | 15 μM | Murai 2003 (Pasquale group) | |
| EphA4 | APYCVYRGSWSC | Murai 2003 (Pasquale group) | |||
| EphA4 | VTMEAINLAFPG | Murai 2003 (Pasquale group) | |||
| EphB1 | EWLSPNLAPSVR | ∼10 μM (antagonist) | >200 μM | Koolpe 2005 (Pasquale group) | |
| EphB2 | SNEWIQPRLPQH | ∼15 μM (antagonist) | 100 μM | Koolpe 2005 (Pasquale group) | Kuchar 201217 Pretze 201318 (Pietzsch group) |
| EphB4 | DHNHNLYNPWRL | ∼200 μM (antagonist) | Koolpe 2005 (Pasquale group) | ||
| EphB4 | TNYLFSPNGPIA | ∼150 μM (antagonist) | >350 μM | Koolpe 2005 (Pasquale group) | |
| EphB4 | TNYLFSPNGPIARAW(K) | ∼15 nM (antagonist) | Koolpe 2005 (Pasquale group) | Li group19−21 |
a
The eponymous amino acid motif within the entire peptide sequence is delineated in bold.