Table 1.
U2OS telomere lengths
| End telomere | End telomere loss | Recombined Ends with ITS | ITS Loss | (TTAGGG) n < 500 bp | % Recombinant Subtelomere Molecules of total analyzed for subtelomere |
Longest Telomere | |
|---|---|---|---|---|---|---|---|
| Chr-parm | Mean Length (kb) ± Std (# telomeres) | (# molecules) | Mean Length (kb) ± Std (# telomeres) | (# molecules) | # molecules (# end, # ITS) | Length (kb) | |
| 1p | 3.8 ± 4.4 (15) | 1 | 4.4 ± 3.6 (4) | 5 | 4 (3,1) | 36 | 17.1 |
| 2p | 2.1 ± 2.5 (12) | 2 | 4.3 ± 4.7 (4) | 2 | 5 (4,1) | 30 | 10.7 |
| 3p | 6.6 ± 8.4 (16) | 0 | 2.9 ± 3.8 (7) | 0 | 5 (1,4) | 30 | 35.8 |
| 4p | 3.2 ± 3.4 (19) | 0 | 1.9 ± 2.1 (2) | 1 | 7 (6,1) | 14 | 11.8 |
| 5p | 3.7 ± 4.2 (21) | 3 | 0.1 ± 0.1 (9) | 3 | 10 (1,9) | 33 | 15.5 |
| 6p | 2.8 ± 1.8 (8) | 0 | 0.6 ± 1.1 (6) | 0 | 6 (1,5) | 43 | 6 |
| 7p | 3.4 ± 7.0 (5) | 0 | 0.5 ± 0.4 (17) | 0 | 12 (3,9) | 77 | 15.8 |
| 8p | 2.7 ± 3.3 (8) | 0 | 0.2 ± 0.2 (3) | 0 | 6 (3,3) | 28 | 8.4 |
| 9p | 2.6 ± 4.9 (7) | 2 | 4.7 ± 7.4 (5) | 3 | 3 (2,1) | 47 | 17.8 |
| 10p | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| 11p | 4.4 ± 5.7 (12) | 0 | 0.7 ± 0.1 (3) | 10 | 1 (1,0) | 52 | 18.1 |
| 12p | 3.8 ± 3.3 (20) | 2 | 27.6 ± 0 (1) | 11 | 2 (2,0) | 35 | 27.6 |
| 13p | nr | nr | |||||
| 14p | nr | nr | |||||
| 15p | nr | nr | |||||
| 16p | INP | INP | |||||
| 17p | INP | INP | |||||
| 18p | 3.7 ± 5.1 (10) | 1 | 0 | 3 | 1 (1,0) | 21 | 16.6 |
| 19p | 7.0 ± 8.1 (29) | 1 | 3.2 ± 0 (1) | 0 | 1 (1,0) | 3 | 35.9 |
| 20p | 7.8 ± 12.2 (20) | 0 | 3.5 ± 0.6 (2) | 1 | 2 (2,0) | 13 | 47.5 |
| 21p | nr | nr | |||||
| 22p | nr | nr | |||||
| Xp/Yp | nr | nr | |||||
| Chr-qarm | |||||||
| 1q | 3.4 ± 3.9 (6) | 1 | 0.6 ± 0.6 (18) | 4 | 8 (1,7) | 76 | 9.4 |
| 2q | 5.5 ± 6.1 (30) | 0 | 1.1 ± 0 (1) | 2 | 5 (5,0) | 9 | 23.8 |
| 3q | 0 (7) | 7 | 0 | 16 | 0 | 70 | N/A |
| 4q | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| 5q | 5.5 ± 5.6 (30) | 0 | 6.6 ± 3.6 (3) | 0 | 2 (2,0) | 9 | 24.2 |
| 6q | 7.8 ± 7.9 (21) | 0 | 4.8 ± 1.5 (2) | 0 | 2 (2,0) | 9 | 28.2 |
| 7q | 4.9 ± 4.4 (11) | 0 | 7.9 ± 5.4 (2) | 0 | 1 (1,0) | 15 | 11.7 |
| 8q | 1.8 ± 3.5 (23) | 6 | 0.4 ± 0.3 (19) | 7 | 15 (6,9) | 52 | 12.9 |
| 9q | 5.2 ± 5.3 (23) | 0 | 3.3 ± 2.5 (6) | 2 | 1 (1,0) | 26 | 17.7 |
| 10q | 3.8 ± 6.4 (2) | 0 | 0 | 2 | 0 | 50 | 13.4 |
| 11q | 4.2 ± 3.1 (7) | 1 | 0.2 ± 0.2 (4) | 1 | 4 (0,4) | 38 | 8.5 |
| 12q | 4.1 ± 4.7 (18) | 4 | 0.7 ± 1.0 (7) | 3 | 7 (3,4) | 31 | 16.5 |
| 13q | 5.5 ± 5.4 (30) | 0 | 8.6 ± 5.8 (2) | 0 | 1 (1,0) | 6 | 20.9 |
| 14q | 2.1 ± 4.8 (6) | 10 | 0 | 4 | 0 | 20 | 16.7 |
| 15q | 4.7 ± 5.7 (17) | 6 | 0.4 ± 0.5 (3) | 4 | 6 (4,2) | 23 | 18.5 |
| 16q | 5.3 ± 5.3 (28) | 4 | 4.5 ± 4.2 (7) | 0 | 4 (2,2) | 18 | 17.1 |
| 17q | 5.4 ± 5.3 (30) | 0 | 6.0 ± 5.9 (2) | 3 | 4 (4,0) | 14 | 18.2 |
| 18q | 0.5 ± 1.2 (5) | 4 | 0.9 ± 0.7 (26) | 5 | 14 (2,12) | 78 | 2.9 |
| 19q | nd | 1 | 1.5 ± 1.1 (25) | 0 | 4 (0,4) | 96 | 5 |
| 20q | 3.4 ± 3.9 (21) | 0 | 1.3 ± 1.1 (3) | 0 | 6 (5,1) | 13 | 14.2 |
| 21q | 4.9 ± 4.7 (12) | 1 | 1.9 ± 4.0 (13) | 17 | 9 (1,8) | 70 | 16.2 |
| 22q | INP | INP | |||||
| Xq/Yq | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| total | 724 | 57 | 182 | 108 | 158 (65,93) | 24 |