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The cytokines M-CSF and RANKL (from osteoblasts) bind to its receptors cFms and RANKL present in osteoclast precursors, respectively. Then the M-CSF stimulates osteoclast precursors proliferation and inhibits their apoptosis. Besides that, RANKL interacts with its receptor RANK in osteoclast precursor cells, then osteoclastognesis is induced.
