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. 2020 Jul 15;40(7):BSR20200407. doi: 10.1042/BSR20200407

Table 1. The source, structure, cells or animal models and mechanisms of ten natural compounds.

Compound name Source Structure Cell lines used for in vitro studies Animal models Dose Mechanisms Studies
Fisetin polyphenolic molecule of flavonoids graphic file with name bsr-40-bsr20200407-i1.jpg Neuron Wistar rats 30 mg/kg Rac1/Cdc42 Jacob [50]
Deacetyl- mycoepoxydiene Phomopsis sp., of costal mangrove graphic file with name bsr-40-bsr20200407-i2.jpg Human breast cancer MCF-7 cells BABL/c mice 5, 10, 20 mg/kg Rac1 Zhao [59]
Diallyl disulfide garlic graphic file with name bsr-40-bsr20200407-i3.jpg Human gastric cancer MGC803 cell line BALB/c nude mice 100mg/kg Rac1 Su [55]
Plectranthoic acid Ficus microcarpa graphic file with name bsr-40-bsr20200407-i4.jpg Prostate cancer cell lines (DU145, PC3, NA22, NB26) N/A N/A Rac1 Akhtar [61]
Cudraxanthone S Cudrania cochinchinensis graphic file with name bsr-40-bsr20200407-i5.jpg N/A N/A N/A Cdc42 Gopal [65]
Panacis Japonici Rhizoma Panax japonicus C. A. Meyer graphic file with name bsr-40-bsr20200407-i6.jpg A2780 cell line N/A N/A Cdc42 Chen [66]
Triptolide Triterygium wilfordii Hook. f. graphic file with name bsr-40-bsr20200407-i7.jpg Sprague–Dawley (SD) rats Sprague–Dawley (SD) rats 100 mg/kg Rac1, Cdc42 Wang [51]
TDB (4,5,40-trihydroxy-3, 30- dimethoxybibenzy) Dendrobium ellipsophyllum Tang and Wang graphic file with name bsr-40-bsr20200407-i8.jpg Human lung cancer H292 cells N/A N/A Rac1/Cdc42 Chaotham [74]
Corosolic acid Actinidia chinensis, graphic file with name bsr-40-bsr20200407-i9.jpg Hepatocellular carcinoma cell lines (Huh7, HepG2 and Hep3B) NOD/SCID mice 5 mg/kg Cdc42 Ku [77]
Gigantol Thai orchid, Dendrobium draconis graphic file with name bsr-40-bsr20200407-i10.jpg Human lung carcinoma cells NCI-H460 and NCI-H292 N/A N/A Cdc42 Charoenrungruang [78]