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. 2020 Jul 16;39:136. doi: 10.1186/s13046-020-01624-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — CASC9 promotes cell metastasis of BCCs in vitro and in vivo. a and c The migratory abilities of BCCs were determined using wound healing assay in vitro. b and d The invasive abilities of BCCs were determined using transwell assay in vitro. e The metastasis of BCCs we also determined using whole-body fluorescent imaging system, and knockdown of CASC9 decreased luciferase signals. f Knockdown of CASC9 significantly reduced the number of pulmonary metastases and metastases size. g Knockdown of CASC9 decreased Ki67 expression of BCCs in vivo. The data are shown as the mean ± SD. *P < 0.05; **P < 0.01