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. 2020 Jul 16;39:136. doi: 10.1186/s13046-020-01624-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — CASC9 positively regulates FZD6 expression via sponging miR-497-5p. a lncLocator results revealed that CASC9 was distributed mostly in the cytoplasm. b The RNA-FISH results revealed that CASC9 was distributed mostly in the cytoplasm of BCCs. c Subcellular localization of CASC9 and control genes analyzed with quantitative RT-PCR in biochemically fractionated SW780 cells. d The bio-information analysis results showed CASC9 and FZD6 have common putative binding sites with miR-497-5p cluster. e Knockdown of CASC9 increased miR-497-5p expression in BCCs. f Overexpressing miR-497-5p decreased FZD6 expression in BCCs. g CASC9 have putative binding sites with miR-497-5p and agomir-497 significantly inhibited luciferase activity of CASC9-Wt group. h The 3’UTR sequence of FZD6 is complementary to the seed sequence of miR-497-5p and agomir-497 significantly inhibited luciferase activity of FZD6-Wt group. i Knockdown of CASC9 decreased the luciferase activity of BCCs transfected with FZD6-Wt. Data are shown as mean ± SD. *P < 0.05; **P < 0.01