Table 2.
Relationship between PET/CT findings and clinical characteristics
| CT findings | ||||
|---|---|---|---|---|
| Fatty mass type (n = 137) | Non-fatty mass type (n = 56) | p value | ||
| Age (years), median (range) | 62 (38–82) | 49 (33–77) | < 0.001 | |
| Postmenopausal, n (%) | 103 (75.7) | 20 (37.7) | < 0.001 | |
| NA | 1 | 3 | ||
| Breast density, n (%) | BIRADs A | 19 (13.9) | 1 (1.8) | < 0.001 |
| B | 55 (40.1) | 5 (8.9) | ||
| C | 49 (35.8) | 17 (30.4) | ||
| D | 14 (10.2) | 33 (58.9) | ||
| Lesion size (mm), median (range) | 9 (2.5–14.0) | 9 (4.0–15.0) | 0.368 | |
| Location of lesion in breast, n (%) | Upper | 94 (78.0) | 37 (71.2) | 0.439 |
| Lower | 27 (22.0) | 15 (28.8) | ||
| Inner | 34 (31.2) | 14 (27.5) | 0.713 | |
| Outer | 75 (68.8) | 37 (72.5) | ||
| Duration between radiation therapy and initial post-cryoablation PET/CT (months), median (range) | 10 (4–33) | 10 (3–26) | 0.744 | |
| Radiation dose (Gy), median (range) | 44.0 (39.6–50.0) | 47.0 (40.0–50.25) | 0.697 | |
| Boost to tumor bed, n (%) | 24 | 18 | 0.032 | |
| Boost to tumor bed (Gy), median (range) | 9 (8.1–12.0) | 9 (2.5–10) | 0.719 | |
| Duration between cryoablation and initial post-cryoablation PET/CT (months), median (range) | 12.0 (1–36) | 12.5 (7–29) | 0.743 | |
| SUVmax, median (range) | 1.30 (0.56–2.32) | 1.49 (0.89–2.24) | < 0.001 | |
| Size of the post-cyroablation change on PET/CT (mm), median (range) | 28 (12–44) | 25 (11–43) | 0.002 | |
PET/CT Positron emission tomography/computed tomography, NA Not available; Breast density BIRADs A, fatty; BIRADs B, scattered fibroglandular density; BIRADs C, heterogeneously dense; BIRADs D, extremely dense
Lesions located in a boundary zone, such as lesions level with the nipple in cephalocaudal height, were excluded from analysis of locations of lesions (Upper or Lower, Inner or Outer)