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Micro-CT analysis. (A) Rat skull 3D rendering at 4- and 8-weeks. Calvarial defects that were left empty did not heal spontaneously for the duration of the study. In contrast, bone healing was gradually achieved when the defects were filled with either ECM or ECM/1.0AMP. (B,C) Bone parameters were quantified as % of tissue volume (BV/TV) within the defect and BD (HU). (*p < 0.05).
