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H&E and MT staining after 8 weeks indicate healing of the defects with new bone formation restricted to the area close to the border of the defects, with the ECM and ECM/1.0AMP showing thicker bone formation compared to 4 weeks. Connective tissue: CT, osteoblast: OB, new bone: NB, blood vessel: BV, osteocytes: OC, woven bone (blue): WB, lamellar bone (red): LB.
