Fig. 2.

EEG spectral power decreases over time in rTg4510 mice. Average total EEG power from 1-week recording periods every 4 weeks in the dark (a) and light (b). Average delta power during NREM sleep from 1-week recording periods every 4 weeks in the dark (c) and light (d). Average theta power from 1-week recording periods every 4 weeks in the dark (e) and light (f). Asterisks (*) denote statistical significance (p < 0.05) at the time point between WT vs Tg, ^†WT vs Tg+DOX, ^‡WT vs tTA, ^¥Tg vs Tg+DOX, ^¢Tg vs tTA and ^¤Tg+DOX vs tTA. Any statistical significance in groups compared with time is described in the text and not shown in the graphs (n = 12–23; p ≤ 0.05)