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. 2020 Jul 15;12:84. doi: 10.1186/s13195-020-00651-0

Fig. 3.

Fig. 3

Sleep architecture changes over time in rTg4510 mice. Least squares means from 1-week recording periods every 4 weeks in the dark and light periods for wakefulness (a, b), NREM sleep (c, d) and REM sleep (e, f), respectively. Asterisks (*) denote statistical significance (p < 0.05) at the time point between WT vs Tg, WT vs Tg+DOX, WT vs tTA, ¥Tg vs Tg+DOX, ¢Tg vs tTA and ¤Tg+DOX vs tTA. Any statistical significance in groups compared with time is described in the text and not shown in the graphs (n = 12–23; p ≤ 0.05)