Fig. 5.

Antitumor effect of TSPAN7 in tumor xenograft models. The mice bearing HCC-LM3 xenografts were divided into three groups and treated with PBS, LV-TSPAN7, LV-shTSPAN7 once every day for a period of 40 days. a Western blotting was used to assess the protein expression after TSPAN7 overexpression and knockdown. b Tumor weight and c tumor volume were measured. d TSPAN7 protein expression in xenograft tissues. e HCC-LM3 cells transfected with LV-TSPAN7 and LV-shTSPAN7 were injected into nude mice (n = 5). Data represent the mean ± SD. **p < 0.01, and ***p < 0.001, as assessed by a Student’s t test