Table 2.
Significant changes of TSPANs expression in transcription level between CRC and normal colorectal tissues (ONCOMINE)
| Gene | Dataset | Normal (cases) | Tumor (cases) | Fold change | T-test | p-value |
|---|---|---|---|---|---|---|
| TSPAN1 | Hong | Colon (12) | Colorectal carcinoma (70) | − 11.253 | − 20.031 | 3.31E–33 |
| Alon | Colon (22) | Colon adenocarcinoma (39) | − 2.360 | − 4.048 | 1.06E–4 | |
| Graudens | Colon (12) | Colorectal carcinoma (18) | − 3.965 | − 7.607 | 5.19E–8 | |
| Kaiser | Colon (5) | Rectosigmoid adenocarcinoma (10) | − 3.848 | − 8.900 | 5.93E–7 | |
| Colon adenocarcinoma (41) | − 3.030 | − 11.170 | 4.07E–10 | |||
| Cecum adenocarcinoma (17) | − 3.448 | − 7.671 | 1.19E–7 | |||
| Colon mucinous adenocarcinoma (13) | − 2.315 | − 6.096 | 7.91E–6 | |||
| Rectal adenocarcinoma (8) | − 3.967 | − 4.779 | 7.70E–4 | |||
| Notterman | Colon (18) | Colon adenocarcinoma (18) | − 5.254 | − 4.381 | 1.56E–4 | |
| Skrzypczak 2 | Colon (10) | Colon carcinoma (5) | − 4.128 | − 16.832 | 1.23E–9 | |
| Colon carcinoma epithelia (5) | − 3.184 | − 8.035 | 1.13E–6 | |||
| Colon adenoma (5) | − 5.101 | − 10.315 | 1.12E–5 | |||
| Colon adenoma epithelia (5) | − 2.263 | − 5.488 | 5.21E–5 | |||
| Skrzypczak | Colon (24) | Colorectal carcinoma (36) | − 3.771 | − 8.073 | 4.98E–11 | |
| Colorectal adenocarcinoma (45) | − 2.004 | − 7.459 | 1.61E–9 | |||
| Gaedcke | Colon (65) | Rectal adenocarcinoma (65) | − 4.740 | − 12.091 | 7.52E–20 | |
| TSPAN2 | Skrzypczak 2 | Colon (10) | Colon carcinoma (5) | 4.984 | 8.441 | 1.86E–6 |
| TSPAN3 | Skrzypczak 2 | Colon (10) | Colon carcinoma (5) | − 2.055 | − 15.355 | 1.07E–9 |
| Colon adenoma (5) | − 2.550 | − 10.121 | 8.17E–8 | |||
| Colon adenoma epithelia (5) | − 2.207 | − 8.118 | 1.55E–5 | |||
| Hong | Colon (12) | Colorectal carcinoma (70) | − 2.156 | − 13.390 | 1.20E–18 | |
| TCGA |
Colon (19) Rectum (3) |
Rectal mucinous adenocarcinoma (6) | − 2.963 | − 9.774 | 8.53E–9 | |
| Cecum adenocarcinoma (22) | − 2.668 | − 9.565 | 2.20E–12 | |||
| Rectosigmoid adenocarcinoma (3) | − 3.161 | − 9.949 | 4.05E–5 | |||
| Rectal adenocarcinoma (60) | − 2.818 | − 11.494 | 1.22E–14 | |||
| Colon adenocarcinoma (101) | − 2.796 | − 12.471 | 1.02E–13 | |||
| Gaedcke | Rectum (65) | Rectal adenocarcinoma (65) | − 2.378 | − 15.151 | 8.00E–30 | |
| Sabates-Bellver |
Colon (25) Rectum (7) |
Colon adenoma (25) | − 2.488 | − 7.802 | 2.92E–9 | |
| Rectal adenoma (7) | − 2.036 | − 3.637 | 0.004 | |||
| Tspan5 | Kaiser | Colon (5) | Cecum adenocarcinoma (17) | 2.751 | 10.138 | 1.62E–9 |
| Rectal mucinous adenocarcinoma (4) | 3.217 | 12.897 | 1.16E–5 | |||
| Colon adenocarcinoma (41) | 3.123 | 14.960 | 1.71E–11 | |||
| Colon mucinous adenocarcinoma (13) | 2.655 | 8.230 | 2.22E–7 | |||
| Rectosigmoid adenocarcinoma (10) | 2.750 | 7.130 | 8.16E–6 | |||
| Rectal adenocarcinoma (8) | 3.173 | 6.741 | 6.16E–5 | |||
| Sabates-Bellver |
Colon (25) Rectum (7) |
Colon adenoma (25) | 2.311 | 9.937 | 1.64E–13 | |
| Hong | Colon (12) | Colorectal carcinoma (70) | 4.927 | 10.849 | 1.76E–10 | |
| Skrzypczak | Colon (24) | Colorectal carcinoma (36) | 2.176 | 6.260 | 4.60E–8 | |
| TCGA |
Colon (19) Rectum (3) |
Rectal mucinous adenocarcinoma (6) | 2.561 | 6.242 | 9.68E–5 | |
| Cecum adenocarcinoma (22) | 2.451 | 6.674 | 4.19E–8 | |||
| Colon adenocarcinoma (101) | 2.337 | 9.041 | 1.98E–12 | |||
| Colon mucinous adenocarcinoma (22) | 2.459 | 6.303 | 1.62E–7 | |||
| Gaedcke | Rectum (65) | Rectal adenocarcinoma (65) | 2.335 | 10.930 | 8.15E–18 | |
| Skrzypczak 2 | Colon (10) | Colon carcinoma (5) | 2.797 | 10.017 | 7.01E–7 | |
| TSPAN7 | TCGA |
Colon (19) Rectum (3) |
Rectal adenocarcinoma (60) | − 9.405 | − 23.392 | 9.78E–38 |
| Colon adenocarcinoma (101) | − 8.713 | − 30.036 | 7.14E–41 | |||
| Colon mucinous adenocarcinoma (22) | − 12.425 | − 15.720 | 3.82E–16 | |||
| Cecum adenocarcinoma (22) | − 8.849 | − 14.091 | 4.39E–15 | |||
| Rectal mucinous adenocarcinoma (6) | − 10.787 | − 12.008 | 6.84E–6 | |||
| Skrzypczak | Colon (24) | Colorectal adenocarcinoma (45) | − 4.777 | − 16.217 | 6.86E–25 | |
| Colorectal carcinoma (36) | − 6.249 | − 12.812 | 1.33E–17 | |||
| Ki |
Colon (28) Liver (13) |
Colon adenocarcinoma (50) | − 3.124 | − 10.532 | 3.60E–17 | |
| Hong | Colon (12) | Colorectal carcinoma (70) | − 7.797 | − 20.686 | 7.73E–30 | |
| Sabates-Bellver |
Colon (25) Rectum (7) |
Colon adenoma (25) | − 5.074 | − 15.401 | 4.54E–18 | |
| Skrzypczak 2 | Colon (10) | Rectal adenoma (7) | − 4.978 | − 8.593 | 3.01E–5 | |
| Colon carcinoma epithelia (5) | − 15.327 | − 33.143 | 2.19E–12 | |||
| Colon adenoma epithelia (5) | − 24.778 | − 29.676 | 4.63E–9 | |||
| Colon carcinoma (5) | − 12.648 | − 37.638 | 7.00E–10 | |||
| Colon adenoma (5) | − 33.012 | − 17.809 | 1.78E–5 | |||
| Notterman | Colon (18) | Colon adenocarcinoma (18) | − 3.434 | − 5.711 | 1.18E–6 | |
| Kaiser | Colon (5) | Rectal mucinous adenocarcinoma (4) | − 4.066 | − 11.930 | 9.67E–6 | |
| Colon mucinous adenocarcinoma (13) | − 4.508 | − 10.063 | 1.05E–7 | |||
| Rectosigmoid adenocarcinoma (10) | − 4.123 | − 7.975 | 1.18E–6 | |||
| Cecum adenocarcinoma (17) | − 3.953 | − 8.093 | 1.53E–7 | |||
| Rectal adenocarcinoma (8) | − 3.626 | − 6.516 | 2.57E–5 | |||
| Colon adenocarcinoma (41) | − 4.189 | − 11.744 | 1.58E–6 | |||
| Gaedcke | Rectum (65) | Rectal adenocarcinoma (65) | − 5.640 | − 20.975 | 3.39E–37 | |
| Graudens | Colon (12) | Colorectal carcinoma (18) | − 2.565 | − 6.685 | 1.57E–7 | |
| TSPAN8 | Ki |
Colon (28) Liver (13) |
Colon adenocarcinoma (50) | − 6.065 | − 8.057 | 8.52E–11 |
| TSPAN9 | Ki |
Colon (28) Liver (13) |
Colon adenocarcinoma (50) | 3.175 | 10.975 | 3.82E–18 |
| TCGA |
Colon (19) Rectum (3) |
Rectosigmoid adenocarcinoma (3) | − 2.230 | − 8.635 | 1.80E–5 | |
| TSPAN11 | TCGA |
Colon (19) Rectum (3) |
Cecum adenocarcinoma (22) | − 3.362 | − 7.883 | 4.28E–10 |
| TSPAN12 | Kaiser | Colon (5) | Rectal mucinous adenocarcinoma (4) | 3.493 | 13.467 | 2.08E–5 |
| Cecum adenocarcinoma (17) | 2.028 | 5.248 | 2.20E–5 | |||
| TSPAN13 | Gaedcke | Rectum (65) | Rectal adenocarcinoma (65) | − 2.281 | − 10.970 | 5.47E–20 |
| TSPAN18 | Sabates-Bellver |
Colon (25) Rectum (7) |
Colon adenoma (25) | − 2.305 | − 4.342 | 4.22E–5 |
| Rectal adenoma (7) | − 2.596 | − 3.192 | 0.007 | |||
| TSPAN22 | TCGA |
Colon (19) Rectum (3) |
Cecum adenocarcinoma (22) | − 3.218 | − 7.807 | 5.38E–10 |
| Rectosigmoid adenocarcinoma (3) | − 4.426 | − 8.958 | 1.45E–4 | |||
| Rectal mucinous adenocarcinoma (6) | − 3.978 | − 6.696 | 5.61E–5 | |||
| Sabates-Bellver |
Colon (25) Rectum (7) |
Rectal adenoma (7) | − 2.588 | − 3.274 | 0.007 | |
| TSPAN25 | Sabates-Bellver |
Colon (25) Rectum (7) |
Rectal adenoma (7) | − 2.037 | − 6.849 | 9.89E–7 |
| TCGA |
Colon (19) Rectum (3) |
Rectal adenocarcinoma (60) | − 3.297 | − 10.147 | 1.20E–15 | |
| Colon adenocarcinoma(101) | − 2.721 | − 9.230 | 8.52E–13 | |||
| TSPAN26 | Sabates-Bellver |
Colon (25) Rectum (7) |
Rectal adenoma (7) | − 4.014 | − 6.888 | 5.78E–7 |
| Colon adenoma (25) | − 5.027 | − 7.327 | 8.84E–10 | |||
| TCGA |
Colon (19) Rectum (3) |
Rectosigmoid adenocarcinoma (3) | − 3.696 | − 12.747 | 2.29E–10 | |
| Rectal adenocarcinoma (60) | − 3.406 | − 11.758 | 1.27E–14 | |||
| Skrzypczak | Colon (24) | Colorectal adenocarcinoma (45) | − 2.920 | − 6.590 | 1.46E–7 | |
| TSPAN28 | Skrzypczak 2 | Colon (10) | Colon carcinoma (5) | 3.109 | 12.960 | 4.16E–9 |
| Colon adenoma epithelia (5) | 2.909 | 8.643 | 3.22E–6 | |||
| Colon adenoma (5) | 2.584 | 7.726 | 2.00E–5 | |||
| Colon carcinoma epithelia (5) | 3.151 | 7.404 | 3.18E–6 | |||
| TSPAN29 | Ki |
Colon (28) Liver(13) |
Colon Adenocarcinoma (50) | 2.054 | 6.211 | 8.79E–9 |
| TSPAN31 | TCGA |
Colon (19) Rectum (3) |
Cecum adenocarcinoma (22) | 3.437 | 15.357 | 6.72E–19 |
| Colon mucinous adenocarcinoma (22) | 3.249 | 10.684 | 8.81E–14 | |||
| Rectal mucinous adenocarcinoma (6) | 3.348 | 9.458 | 8.89E–7 | |||
| Rectal adenocarcinoma (60) | 3.181 | 15.893 | 4.15E–19 | |||
| Colon adenocarcinoma (101) | 3.374 | 18.022 | 3.27E–18 | |||
| Rectosigmoid adenocarcinoma (3) | 4.256 | 12.487 | 1.86E–5 | |||
| Skrzypczak 2 | Colon (10) | Colon adenoma (5) | − 2.901 | − 12.980 | 2.95E–8 | |
| Colon carcinoma epithelia (5) | − 2.465 | − 13.992 | 2.78E − 9 | |||
| TSPAN32 | TCGA |
Colon (19) Rectum (3) |
Rectal mucinous adenocarcinoma (6) | − 2.739 | − 10.351 | 3.43E–8 |
| Cecum adenocarcinoma (22) | − 2.077 | − 7.109 | 6.50E–9 | |||
| TSPAN33 | Skrzypczak 2 | Colon (10) | Colon carcinoma (5) | 2.104 | 10.676 | 1.37E–7 |
CRC colorectal cancer