Table 3.
Categories of gallbladder or biliary disease complications (pooled algorithm-based and non–algorithm-based events)
| Category of gallbladder or biliary complication | Liraglutide, n = 4,668 |
Placebo, n = 4,672 |
Total, n = 9,340 |
||||||
|---|---|---|---|---|---|---|---|---|---|
| N | % | E | N | % | E | N | % | E | |
| All events | 141 | 3.02 | 155 | 88 | 1.88 | 113 | 229 | 2.45 | 268 |
| Uncomplicated gallbladder stones | 16 | 0.34 | 17 | 5 | 0.11 | 7 | 21 | 0.22 | 24 |
| Complicated gallbladder stones | 52 | 1.11 | 54 | 40 | 0.86 | 42 | 92 | 0.99 | 96 |
| Leading to cholecystectomy | 31 | 0.66 | 32 | 22 | 0.47 | 22 | 53 | 0.57 | 54 |
| Cholecystitis | 51 | 1.09 | 56 | 33 | 0.71 | 35 | 84 | 0.90 | 91 |
| Without gallbladder stones | 19 | 0.41 | 21 | 8 | 0.17 | 8 | 27 | 0.29 | 29 |
| With gallbladder stones | 30 | 0.64 | 33 | 22 | 0.47 | 24 | 52 | 0.56 | 57 |
| Unknown stone status | 2 | 0.04 | 2 | 3 | 0.06 | 3 | 5 | 0.05 | 5 |
| Leading to cholecystectomy | 39 | 0.84 | 43 | 26 | 0.56 | 28 | 65 | 0.70 | 71 |
| Biliary obstruction | 25 | 0.54 | 28 | 16 | 0.34 | 29 | 41 | 0.44 | 57 |
| Bile duct stones | 22 | 0.47 | 24 | 13 | 0.28 | 18 | 35 | 0.37 | 42 |
| Bile duct stenosis | 3 | 0.06 | 4 | 3 | 0.06 | 11 | 6 | 0.06 | 15 |
| Intervention | |||||||||
| ERCP | 9 | 0.19 | 11 | 6 | 0.13 | 18 | 15 | 0.16 | 29 |
| Papillotomy | 4 | 0.09 | 5 | 6 | 0.13 | 10 | 10 | 0.11 | 15 |
| Stenting (biliary prosthesis) | 1 | 0.02 | 2 | 2 | 0.04 | 11 | 3 | 0.03 | 13 |
| Cholecystectomy | 12 | 0.26 | 13 | 8 | 0.17 | 9 | 20 | 0.21 | 22 |
Seven events and six patients were excluded, since the seven events were assessed to be unrelated to biliary disease. The seven excluded events occurred in seven patients, but, as one of the patients also had another gallbladder- or biliary tract–related event, this patient was included in the analyses for the other event. For some patients, cholecystectomy was reported for two separate events with the same start date. Therefore, more cholecystectomy events than patients with cholecystectomy are listed for some categories of gallbladder or biliary disease. E, number of events; n, number of patients; N, number of patients with an event; %, percentage of patients.