Table 1.
Pathological characteristics of phenotypes in Alzheimer's disease and FTLD
| Alzheimer's disease |
FTLD |
|||||||
|---|---|---|---|---|---|---|---|---|
| Amnestic (n = 98) | Non-amnestic (n = 20) | Chi-square |
Amnestic (n = 5) | Non-amnestic (n = 59) | Chi-square |
|||
| χ 2 | P | χ 2 | P | |||||
| APOE ε4 alleles | ||||||||
| 0 | 32 (33%) | 11 (55%) | 2 (40%) | 50 (86%) | ||||
| 1 | 48 (49%) | 8 (40%) | 4.4 | 0.12 | 2 (40%) | 8 (14%) | 14.8 | 0.011 |
| 2 | 18 (18%) | 1 (5%) | 1 (20%) | 0 (0%) | ||||
| Thal stage | ||||||||
| 0 | 0 (0%) | 0 (0%) | 1.9 | 0.55 | 0 (0%) | 26 (51%) | 1.9 | 0.50 |
| 1 | 2 (3%) | 0 (0%) | 1(100%) | 17 (33%) | ||||
| 2 | 1 (1%) | 1 (6%) | 0 (0%) | 5 (10%) | ||||
| 3 | 76 (96%) | 16 (94%) | 0 (0%) | 3 (6%) | ||||
| CERAD stage | ||||||||
| 0 | 1 (1%) | 0 (0%) | 2.9 | 0.41 | 2 (50%) | 44 (75%) | 9.0 | 0.08 |
| 1 | 1 (1%) | 0 (0%) | 0 (0%) | 10 (17%) | ||||
| 2 | 5 (5%) | 3 (15%) | 1 (25%) | 4 (7%) | ||||
| 3 | 90 (93%) | 17 (85%) | 1 (25%) | 1 (2%) | ||||
| Braak stage | ||||||||
| 0 | 0 (0%) | 0 (0%) | 0.17 | 1.0 | 2 (50%) | 20 (42%) | 1.2 | 0.70 |
| 1 | 0 (0%) | 0 (0%) | 2 (50%) | 17 (35%) | ||||
| 2 | 3 (3%) | 1 (5%) | 0 (0%) | 10 (21%) | ||||
| 3 | 93 (97%) | 19 (95%) | 0 (0%) | 1 (2%) | ||||
| Atrophy rating | ||||||||
| 0 | 5 (5%) | 2 (10%) | 1.9 | 0.62 | 0 (0%) | 2 (3%) | 1.5 | 0.71 |
| 1 | 31 (32%) | 7 (35%) | 0 (0%) | 14 (24%) | ||||
| 2 | 29 (30%) | 7 (35%) | 2 (50%) | 20 (34%) | ||||
| 3 | 33 (34%) | 4 (20%) | 2 (50%) | 22 (38%) | ||||
| Wilcox | Wilcox | |||||||
| W | P | W | P | |||||
| Median neuronal loss | ||||||||
| Median | 2.0 | 2.5 | 1.0 | 2.0 | ||||
| IQR | 1.0 | 1.3 | 262.5 | 0.10 | 1.0 | 1.4 | 50 | 0.43 |
| n | 61 | 12 | 3 | 46 | ||||
Contingency table by primary pathology (Alzheimer’s disease, FTLD) and phenotype (amnestic, non-amnestic) for number of APOE ε4 alleles, Thal Stage, CERAD stage, Braak stage, and atrophy. Median, interquartile range (IQR), and sample size (n) are reported for median neuronal loss. Chi-square and Mann-Whitney-Wilcox tests compare phenotypes (amnestic and non-amnestic) within each pathological group (Alzheimer’s disease and FTLD); χ2, W, and P-values are reported. Information was not available for all subjects.