Figure 1.

Global burden of CNV by overall length across four epilepsy types. Rare CNV burden observed in the different epilepsy types is shown for (A) deletions and (B) duplications. Odds ratios (OR) and P-values were calculated using a binomial logistic regression for rare CNVs with sex as a covariate in three different categories (overall genomic sequence loss in one individual of >2 Mb, 500 kb–2 Mb and <500 kb). UE = unclassified epilepsies; *P-values surpassing the Bonferroni multiple testing for 30 tests cut-off (*P < 2.1 × 10⁻³).