Table 1.
Baseline demographic, clinical data, and global brain, brainstem, and spinal cord MRI characteristics
| All patients | CIS | RRMS | SPMS | PPMS | |
|---|---|---|---|---|---|
| (n = 290) | (n = 22) | (n = 198) | (n = 39) | (n = 31) | |
| Baseline demographic and clinical data | |||||
| Sex F/M | 185/105 | 15/7 | 128/70 | 24/15 | 18/13 |
| Mean ± SD age, years | 42.3 ± 12.2 | 42.7 ± 12.2 | 38.2 ± 9.8 | 51.9 ± 8.6 | 56.5 ± 12.6 |
| Mean ± SD disease duration, yearsa | 9.0 ± 9.8 | 4.6 ± 4.4 | 6.1 ± 7.1 | 22.0 ± 10.3 | 16.3 ± 10.9 |
| Median EDSS (range) | 2.0 (0.0–8.0) | 1.0 (0.0–2.0) | 1.5 (0.0–8.0) | 6.0 (3.0–8.0) | 6.0 (1.5–8.0) |
| Median pyramidal functional system score (range)a | 1.0 (0.0–5.0) | 0.0 (0.0–2.0) | 0.0 (0.0–4.0) | 3.0 (1.0–5.0) | 3.0 (0.0–5.0) |
| Median TWT score (range)a | 5.0 (2.8–112.0) | 4.0 (3.6–5.2) | 4.6 (2.8–34.0) | 8.9 (4.5–40.0) | 8.2 (4.0–112.0) |
| Median 9HPT (range)a | 21.7 (16.1–81.6) | 21.4 (18.7–28.3) | 21.4 (16.1–65.0) | 34.0 (23.4–81.6) | NA |
| Global brain, brainstem, and spinal cord MRI characteristics | |||||
| Brain | |||||
| Median absolute lesion volume (range), cm3 | 3.5 (0–56.1) | 0.7 (0.1–17.2) | 3.1 (0–51.5) | 7.9 (0.09–51.3) | 5.9 (0.4–56.1) |
| Median brain parenchymal fraction (range) | 0.79 (0.65–0.90) | 0.79 (0.72–0.82) | 0.80 (0.65–0.90) | 0.76 (0.65–0.82) | 0.77 (0.68–0.83) |
| Brainstem | |||||
| Median absolute lesion volume, cm3 (range) | 0.6 (0–14.4) | 0.1 (0–5.6) | 0.5 (0–8.6) | 1.8 (0–10.4) | 1.3 (0–14.4) |
| Cervical spinal cord | |||||
| Median absolute lesion volume cm3 (range), | 0.2 (0–2.1) | 0.1 (0–0.4) | 0.2 (0–2.1) | 0.5 (0.1–2.1) | 0.5 (0–1.6) |
| Median cord cross-sectional area across C2–C3 vertebral levels (range), mm2 | 72.7 (44.2–124.3) | 69.7 (61.8–82.6) | 76.2 (52.5–124.3) | 63.1 (44.2–84.5) | 64.0 (52.6–80.8) |
a
The disease duration was available for 262 subjects, the pyramidal functional system score for 206 subjects, the TWT score for 222 subjects and the 9HPT for 118 subjects.
NA = not available for PPMS patients.