Table 2.

Multivariate linear regression of EDSS, pyramidal functional system score, 9HPT and TWT

	Standardized β coefficient a	SE	P-value
EDSS score (R2 = 0.60)
Age, years	0.28	0.06	<0.0001
Disease duration, years	0.18	0.07	0.007
Normalized brain CST lesion volume	0.11	0.05	0.02
Normalized brainstem CST lesion volume	0.09	0.04	0.02
Normalized cervical cord CST lesion volume	0.31	0.04	<0.0001
Spinal cord cross sectional area, mm2	−0.12	0.06	0.02
Centreb
Centre 2	−0.15	0.20	0.5
Centre 3	−0.09	0.29	0.7
Centre 5	−0.11	0.22	0.6
Centre 6	0.53	0.28	0.05
Centre 7	0.37	0.21	0.07
Centre 8	−0.09	0.22	0.7
Pyramidal functional system score (R2 = 0.55)
Age, years	0.25	0.06	<0.0001
Disease duration, years	0.16	0.07	0.02
Normalized spinal cord CST lesion volume	0.32	0.05	<0.0001
Brain parenchymal fraction	−0.20	0.06	0.0009
9HPT (R2 = 0.36)
Age, years	0.43	0.09	<0.0001
Normalized brainstem CST lesion volume	0.23	0.09	0.01
Normalized spinal cord CST lesion volume	0.28	0.07	0.0002
TWT (R2 = 0.11)
Disease duration, years	0.22	0.04	<0.0001

^aExcept for the centre.

^bPatients from Centre 4 were not included in multiple linear regression model (no disease duration available for these patients).