TABLE 3.

Region‐based standardized mean differences comparing cognitively unimpaired and cognitively impaired responders to norms from 2799 cognitively normal individuals in the general population

	CU versus norms		CI versus norms
Region	D	P	D	P
Banks superior temporal sulcus	−0.26	.362	−0.80	.007
Caudal anterior	0.71	.015	0.32	.262
Caudal middle frontal	0.77	.009	−0.17	.543
Cuneus	1.29	<.001	−0.05	.874
Entorhinal	−3.33	<.001	−2.64	<.001
Fusiform	−1.75	<.001	−2.25	<.001
Inferior parietal	0.92	.002	−0.28	.332
Inferior temporal	−0.98	.001	−1.92	<.001
Isthmus cingulate	0.77	.009	0.07	.796
Lateral occipital	1.26	<.001	0.00	.998
Lateral orbitofrontal	0.39	.173	−0.45	.122
Lingual	0.71	.015	−0.53	.066
Medial orbitofrontal	0.20	.489	−0.92	.002
Middle temporal	−1.22	<.001	−2.12	<.001
Parahippocampal	−1.16	<.001	−1.71	<.001
Para‐central	0.72	.014	−0.11	.706
Pars opercularis	0.23	.418	−0.85	.004
Pars orbitalis	−0.01	.981	0.11	.687
Pars triangularis	0.44	.130	−0.09	.747
Pericalcarine	0.41	.148	−0.44	.125
Postcentral	1.28	<.001	0.08	.772
Posterior cingulate	0.82	.006	0.15	.596
Precentral	0.40	.160	−1.11	<.001
Precuneus	0.77	.009	−0.49	.088
Rostral anterior cingulate	0.03	.905	−0.58	.047
Rostral middle frontal	1.05	.001	−0.23	.412
Superior frontal	0.99	.001	−0.31	.276
Superior parietal	1.04	.001	−0.15	.603
Superior temporal	−0.95	.002	−2.23	<.001
Supramarginal	0.72	.014	−0.74	.012
Frontal pole	1.06	<.001	−0.14	.625
Temporal pole	−1.15	<.001	−1.50	<.001
Transverse temporal	0.60	.039	−0.73	.013
Insula	0.32	.260	−0.81	.006

Note: P‐values provided in the rightmost column were derived from one‐sample t‐tests. Regions where cortical thickness was significantly reduced upon accounting for the false discovery rate were highlighted in Bold. Codes to abbreviations are provided in Table 2.

Abbreviations: CU, cognitively unimpaired; CI, Cognitively impaired; D, Standardized Mean Differences (Cohen's D).