FIGURE 4.

Regional brain volume analysis in cerebrospinal fluid (CSF) subgroup. Effect size map showing the relation between log white matter hyperintensity (WMH) volume and regional gray matter (GM) volume using standardized beta coefficients (Red: GM volume smaller in patients with higher log WMH volume; blue: GM volume smaller in patients with lower log WMH volume). A, CSF amyloid‐negative patients (n = 261); (B) CSF amyloid‐positive patients (n = 227). The stratified analyses show that the effect is highly dependent on CSF amyloid status. While amyloid‐positive patients have a lower GM volume than amyloid‐negative patients, the association between higher log WMH volume and more GM atrophy was more pronounced in several brain regions for amyloid‐negative patients only. * Bonferroni‐corrected P < .05