Table 2.
Thirty-two significant genes were identified for PVWMH using gene-based tests (p<2.66e-6). Thirteen of these genes (chr17) were also significant for DWMH (*).
| GENE | CHR | START | STOP | N SNPS | N | p PVWMH | p DWMH |
|---|---|---|---|---|---|---|---|
| WBP2 | 17 | 73841780 | 73852588 | 28 | 24682 | 3.19E-26 | 1.16E-21* |
| TRIM65 | 17 | 73876416 | 73893084 | 52 | 24555 | 7.73E-24 | 9.12E-19* |
| TRIM47 | 17 | 73870242 | 73874656 | 13 | 24185 | 1.70E-23 | 9.04E-19* |
| RP11–552F3.12 | 17 | 73894726 | 73926210 | 53 | 24351 | 2.15E-20 | 1.76E-15* |
| FBF1 | 17 | 73905655 | 73937221 | 55 | 24338 | 3.98E-17 | 1.23E-13* |
| GALK1 | 17 | 73747675 | 73761792 | 36 | 24307 | 6.34E-16 | 3.23E-14* |
| MRPL38 | 17 | 73894724 | 73905899 | 21 | 24481 | 7.62E-15 | 1.18E-13* |
| UNC13D | 17 | 73823306 | 73840798 | 73 | 23788 | 3.10E-14 | 1.22E-13* |
| UNK | 17 | 73780681 | 73821886 | 120 | 22768 | 3.28E-13 | 4.85E-10* |
| H3F3B | 17 | 73772515 | 73781974 | 23 | 24009 | 4.43E-12 | 1.41E-10* |
| SH3PXD2A | 10 | 105348285 | 105615301 | 788 | 24847 | 8.43E-12 | 0.21731 |
| ACOX1 | 17 | 73937588 | 73975515 | 151 | 24198 | 7.72E-11 | 1.1E-09* |
| EVPL | 17 | 74000583 | 74023533 | 67 | 24582 | 1.26E-10 | 2.82E-14* |
| PLEKHG1 | 6 | 150920999 | 151164799 | 1022 | 24922 | 1.59E-10 | 0.011765 |
| WDR12 | 2 | 203739505 | 203879521 | 322 | 23753 | 2.53E-10 | 0.00104 |
| ICA1L | 2 | 203640690 | 203736708 | 224 | 23843 | 8.44E-10 | 0.001301 |
| CARF | 2 | 203776937 | 203851786 | 157 | 24076 | 2.41E-09 | 0.001763 |
| NMT1 | 17 | 43128978 | 43186384 | 221 | 24766 | 7.18E-08 | 0.00034 |
| CDK3 | 17 | 73996987 | 74002080 | 12 | 24433 | 8.54E-08 | 1.82E-08* |
| OBFC1 | 10 | 105642300 | 105677963 | 99 | 25461 | 1.41E-07 | 0.054127 |
| NOS3 | 7 | 150688083 | 150711676 | 58 | 24608 | 1.73E-07 | 0.000371 |
| DCAKD | 17 | 43100708 | 43138473 | 111 | 25229 | 2.60E-07 | 0.000363 |
| DYDC2 | 10 | 82104501 | 82127829 | 91 | 25050 | 2.88E-07 | 0.003460 |
| NBEAL1 | 2 | 203879602 | 204091101 | 367 | 23413 | 3.83E-07 | 0.040539 |
| NEURL1 | 10 | 105253736 | 105352309 | 296 | 25038 | 4.84E-07 | 0.098303 |
| MAT1A | 10 | 82031576 | 82049440 | 66 | 25295 | 4.90E-07 | 0.002421 |
| TSPAN14 | 10 | 82213922 | 82292879 | 213 | 24731 | 6.73E-07 | 0.006605 |
| CALCRL | 2 | 188207856 | 188313187 | 278 | 24309 | 7.87E-07 | 0.000574 |
| KLHL24 | 3 | 183353356 | 183402265 | 207 | 24356 | 1.29E-06 | 0.002571 |
| POLR2F | 22 | 38348614 | 38437922 | 105 | 23525 | 1.94E-06 | 0.252540 |
| VCAN | 5 | 82767284 | 82878122 | 316 | 24248 | 2.52E-06 | 0.065044 |
| COL4A2 | 13 | 110958159 | 111165374 | 1140 | 24876 | 2.61E-06 | 0.365300 |
Notes: Those loci bolded have not been previously associated with total WMH.