Fig. 3.

Epitope locations on the primary sequence of Aβ, for antibodies currently or recently in clinical trials. Black bars indicate epitope locations; gray bars indicate presumptive epitopes that likely subsume the actual epitope as a subset of the gray region. Gradient filling for MEDI-1814 represents the incompletely characterized epitope, but with known Aβ₄₂ selectivity. Gantenerumab and NPT088 both have discontiguous epitopes on Aβ. Magenta region on the epitope for donanemab represents pyroglutamate at amino acid position 3. Amino acids in the primary sequence of Aβ are colored as follows. Red: negatively charged; Blue: positively charged; Green: aromatic; Yellow background: hydrophobic. The significant hydrophobicity and absence of aromatic residues in the C-terminal region is noteworthy. Specific epitope locations are listed in Table 1. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)