Table 2.
Mortality outcome and predictors at admission.
| TCZ subpopulation (n = 77) | OR (95%CI) | p | |
|---|---|---|---|
| Demographics | |||
| Age | 1.04 (0.97–1.09) | .235 | |
| Gender | |||
| - Females | 2/27 (7.4) | 1.00 (ref) | – |
| - Males | 8/50 (16.0) | 2.38 (0.47–12.1) | .296 |
| Nosocomial case | |||
| - No | 9/75 (12.0) | 1.00 (ref) | - |
| - Yes | 1/2 (50.0) | 7.22 (0.41–125.87) | .175 |
| Long-term care resident | |||
| - No | 10/77(13.0) | NC | – |
| - Yes | 0/0 (0.0) | ||
| Health professional | |||
| - No | 10/68 (14.7) | NC | – |
| - Yes | 0/9 (0.0) | ||
| Comorbidities | |||
| Hypertension | |||
| - No | 5/45 (11.1) | 1.00 (ref) | - |
| - Yes | 5/32 (15.6) | 1.48 (0.39–5.61) | .563 |
| Diabetes | |||
| - No | 6/61 (9.8) | 1.00 (ref) | - |
| - Yes | 4/16 (25.0) | 3.06 (0.75–12.53) | .121 |
| Obesity | |||
| - No | 6/49 (12.2) | 1.00 (ref) | - |
| - Yes | 3/26 (11.5) | 0.94 (0.21–4.09) | .929 |
| Cardiovascular disease | |||
| - No | 6/71 (8.4) | 1.00 (ref) | - |
| - Yes | 2/6 (33.3) | 4.17 (0.62–27.77) | .140 |
| Chronic respiratory disease | |||
| - No | 9/66 (13.6) | 1.00 (ref) | - |
| - Yes | 1/11 (9.1%) | 0.61 (0.07–5.37) | .657 |
| Immunosuppression | |||
| - No | 10/73 (13.7) | NC | - |
| - Yes | 0/4 (0.0) | – | |
| Charlson index | 1.42 (0.99–2.04) | .052 | |
| - <3 | 4/44 (9.1) | 1.00 (ref) | - |
| - ≥3 | 6/33 (18.2) | 2.22 (0.57–8.62) | .248 |
| 10-years expected survivala | |||
| - ≥90% | 3/38 (7.9) | 1.00 (ref) | - |
| - <90% | 6/36 (16.7) | 2.33 (0.54–10.14) | .258 |
| Clinical Presentation | |||
| Clinical durationb | |||
| - ≥7 | 4/40 (10.0) | 1.00 (ref) | - |
| - <7 | 6/37 (16.2) | 0.57 (0.15–2.22) | .421 |
| Fever | |||
| - No | 0/7 (0) | NC | - |
| - Yes | 10/70 (14.3) | – | |
| Dry cough | |||
| - No | 1/25 (4.0) | 1.00 (ref) | - |
| - Yes | 9/52 (17.3) | 4.81 (0.57–40.39) | .148 |
| Wet cough | |||
| - No | 8/61 (13.1) | 1.00 (ref) | - |
| - Yes | 2/16 (12.5) | 0.95 (0.18–4.96) | .948 |
| Dyspnea | |||
| - No | 3/28 (10.7) | 1.00 (ref) | - |
| - Yes | 7/49 (14.3) | 1.33 (0.32–5.64) | .696 |
| Diarrhoea | |||
| - No | 7/50 (14.0) | 1.00 (ref) | - |
| - Yes | 3/27 (11.1) | 0.77 (0.18–3.25) | .720 |
| Confusion | |||
| - No | 8/72 (11.1) | 1.00 (ref) | - |
| - Yes | 2/5 (40.0) | 5.25 (0.76–36.33) | .093 |
| Fatigue | |||
| - No | 3/34 (8.8) | 1.00 (ref) | - |
| - Yes | 7/41 (17.1) | 2.13 (0.51–8.96) | .303 |
| Myalgias-arthralgias | |||
| - No | 6/51 (11.8) | 1.00 (ref) | - |
| - Yes | 4/24 (16.7) | 1.50 (0.38–5.91) | .562 |
| Anosmia-dysgeusia | |||
| - No | 9/64 (14.1) | 1.00 (ref) | - |
| - Yes | 1/10 (10.0) | 0.68 (0.08–6.02) | .728 |
| Initial Assessment | |||
| Oximetry at room air | |||
| - ≥94% | 2/25 (8.0) | 1.00 (ref) | - |
| - <94% | 8/49 (16.3) | 2.24 (0.44–11.47) | .332 |
| PaO2:FiO2 | 0.98 (0.98–0.99) | .007 | |
| - ≥300 | 2/47 (4.3) | 1.00 (ref) | - |
| - <300 | 8/29(27.6) | 8.57 (1.67–43.91) | .010 |
| Respiratory rate | |||
| - ≤24 | 2/16 (12.5) | 1.00 (ref) | - |
| - >24 | 4/25 (16.0) | 1.33 (0.21–8.28) | .758 |
| Systolic BP | |||
| - ≥100 | 8/68 (11.8) | 1.00 (ref) | - |
| - <100 | 2/5 (40.0) | 5.00 (0.72–34.63) | .103 |
| Diastolic BP | |||
| - ≥60 | 9/65 (13.8) | 1.00 (ref) | - |
| - <60 | 1/8 (12.5) | 0.89 (0.09–8.11) | .917 |
| Heart rate | |||
| - ≤100 | 6/48 (12.5) | 1.00 (ref) | - |
| - >100 | 4/26 (15.4) | 1.27 (0.33–4.99) | .729 |
| CURB65 | |||
| - <3 | 2/31 (6.5) | 1.00 (ref) | - |
| - ≥3 | 4/6 (66.7) | 29.00 (3.15–267.37) | .003 |
| eGFR | |||
| - ≥60 | 7/64 (10.9) | 1.00 (ref) | - |
| - <60 | 3/11 (27.3) | 3.05 (0.65–14.27) | .156 |
| Leukocytes | 1.00 (1.00–1.00) | .127 | |
| Lymphocytes | .99 (.99–1.01) | .201 | |
| C-reactive protein | 1.03 (0.96–1.11) | .393 | |
| Procalcitonin | .88 (0.36–2.14) | .777 | |
| Ferritin | 1.00 (0.99–1.00) | .415 | |
| Lactate dehydrogenase | 1.01 (1.00–1.01) | .034 | |
| D-dimers | 1.06 (0.99–1.13) | .090 | |
| Interleukin 6 | 0.99 (0.98–1.01) | .294 | |
| Troponin T | 1.01 (0.97–1.05) | .598 | |
| Brain natriuretic peptide | 1.00 (0.99–1.01) | .884 | |
| Creatine phosphokinase | 0.99 (0.99–1.01) | .562 | |
| Aspartate aminotransferase | .99 (.973–1.01) | .489 | |
| Alanine aminotransferase | 0.99 (0.97–1.01) | .477 | |
| Opacities of lung surface on X-rays | |||
| - ≤50% | 4/52 (7.6) | 1.00 (ref) | - |
| - >50% | 5/25 (20.0) | 2.35 (0.61–9.02) | .213 |
Data shown as n (%) unless specified otherwise. For units of the variable, please refer to Table 1. In bold, statistically significant differences.
a
10-years expected survival derived from Charlson comorbidity index score.
b
Days of symptoms before admission. OR: odds ratio, 95%CI: 95% confidence interval, NC: not calculable.