Fig. 2.

3D serial section reconstruction of the urogenital sinus (UGS) from gestation day (GD) 19 male CD-1 mice exposed to low doses of bisphenol A (BPA) and ethinyl estradiol (EE) from gestation day 14-18 via feeding the pregnant dam. UGS depicted for each treatment was closest to the group mean. There was a marked alteration in urethra shape, particularly at the junction of the bladder and urethra, which is constricted (*) in mice exposed to estrogenic chemicals compared to controls. In addition, the UGS region (prostatic sulcus or colliculus, arrow) is significantly enlarged by BPA compared to controls, based on data published in Timms et al. 2005 [59].