Table 1.
Three parallel but distinct studies (i.e.: Experiments 1, 2, 3a and 3b) used to examine the relationship of genotype-to-phenotype expression in LID.
Experiment ID | Experiment Name | Rat Strain | Principal Experimental Endpoint |
---|---|---|---|
1 | Gene Array Exploration | Sprague Dawley | Differential Gene Expression in LID+ vs LID− Subjects |
2 | Chronic LID+ vs Acute LID+ | Sprague Dawley | Differential Transcript and Protein Expression in Chronically vs Acutely Dyskinogenic Subjects |
3a | F344 LID+ vs Lewis LID− | F344 & Lewis | Differential LID and Transcript Expression and DA & 5-HT content in F344 LID+ vs Lewis LID− Subjects |
3b | F344 LID+ vs Lewis LID− | F344 & Lewis | Differential Extracellular Striatal DA, 5-HT, & NE in F344 LID+ vs Lewis LID− Subjects |