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. 2020 Jul 15;202(2):259–274. doi: 10.1164/rccm.201906-1199OC

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Figure 6. — Correlation between gene expression and pulmonary function indices associated with obesity-related asthma. Expression of several genes correlated with percentage FEV₁/FVC ratio and percent predicted expiratory reserve volume (ERV) in obese children with asthma but not in normal-weight children with asthma. Representative correlations of FEV₁/FVC and ERV with differentially expressed genes enriched in Rho-GTPase pathways (A) PRKCG (protein kinase Cγ), (B) MYH13 (myosin heavy chain 13), and (C) PLXNB3 (plexin B3), genes that influence Rho-GTPases (D) CHN2 (chimerin 2) and (E) WHRN (whirlin) and genes associated with cellular mechanisms related to Rho-GTPases, including actin polymerization, (F) MYO1C (myosin IC), (G) MAP1B (microtubule-associated protein 1B), and (H) ADAMTS2 (a disintegrin and metalloproteinase with thrombospondin type 1, motif 2) are shown. (I) RPS27L (40S ribosomal protein S27-like) was the one expression quantitative trait loci target gene that was differentially expressed in obese asthma T-helper cells and was also associated with FEV₁/FVC ratio and ERV.

Figure 6. — Correlation between gene expression and pulmonary function indices associated with obesity-related asthma. Expression of several genes correlated with percentage FEV₁/FVC ratio and percent predicted expiratory reserve volume (ERV) in obese children with asthma but not in normal-weight children with asthma. Representative correlations of FEV₁/FVC and ERV with differentially expressed genes enriched in Rho-GTPase pathways (A) PRKCG (protein kinase Cγ), (B) MYH13 (myosin heavy chain 13), and (C) PLXNB3 (plexin B3), genes that influence Rho-GTPases (D) CHN2 (chimerin 2) and (E) WHRN (whirlin) and genes associated with cellular mechanisms related to Rho-GTPases, including actin polymerization, (F) MYO1C (myosin IC), (G) MAP1B (microtubule-associated protein 1B), and (H) ADAMTS2 (a disintegrin and metalloproteinase with thrombospondin type 1, motif 2) are shown. (I) RPS27L (40S ribosomal protein S27-like) was the one expression quantitative trait loci target gene that was differentially expressed in obese asthma T-helper cells and was also associated with FEV₁/FVC ratio and ERV.