Table 2.
Differential Expression of RPS27L in Obese Children with Asthma Is Associated with T-Helper Cell Subtypes and an Expression and Quantitative Trait Locus
| Variables | Model 1 |
Model 2 |
Model 3* |
|||
|---|---|---|---|---|---|---|
| β-Value (95% CI) | P Value | β-Value (95% CI) | P Value | β-Value (95% CI) | P Value | |
| Study group | −0.08 (−0.15 to 0.001) | 0.053 | −0.07 (−0.14 to −0.003) | 0.049 | −0.06 (−0.13 to 0.01) | 0.1 |
| Cluster 0 | — | — | 0.49 (−0.30 to 1.27) | 0.22 | 0.33 (−0.50 to 1.16) | 0.43 |
| Cluster 1 | — | — | 1.01 (−0.04 to 0.01) | 0.06 | 0.75 (−0.39 to 1.89) | 0.19 |
| Cluster 2 | — | — | −0.54 (−0.97 to −0.11) | 0.01 | −0.59 (−1.06 to −0.12) | 0.01 |
| Cluster 4 | — | — | −0.59 (−1.31 to 0.12) | 0.10 | −0.64 (−1.38 to 0.09) | 0.08 |
| Genotype (T/C)† | — | — | — | — | −0.17 (−0.26 to −0.08) | <0.001 |
| Genotype (C/C)† | — | — | — | — | −0.16 (−0.34 to 0.03) | 0.09 |
Definition of abbreviations: CI = confidence interval; RPS27L = 40S ribosomal protein S27-like.
*
The proportion of memory T-helper cells (cluster 2) and the minor allele were independent predictors of gene expression.
†
Major allele homozygous (T/T) was the reference group.