Table 1.
Clinical Characteristics of 321 Critically Ill Patients Grouped by Median Alternative Complement Pathway Function
| Total (N = 321) | AH50 < Median (n = 160) | AH50 ≥ Median (n = 161) | P Value | |
|---|---|---|---|---|
| Age, yr, median (IQR) | 57 (45–67) | 56 (45–67) | 58 (45–67) | 0.56 |
| Sex, F, n (%) | 142 (44.2) | 69 (43.1) | 73 (45.3) | 0.69 |
| Race, n (%) |
0.41 | |||
| White | 297 (92.5) | 150 (93.8) | 147 (91.3) | |
| Black | 24 (7.5) | 10 (6.3) | 14 (8.7) | |
| Admission source OSH, n (%) | 205 (63.9) | 107 (66.9) | 98 (60.9) | 0.26 |
| ARDS, n (%) | 107 (33.3) | 53 (33.1) | 54 (33.5) | 0.94 |
| Suspected sepsis, n (%) | 202 (62.9) | 99 (61.9) | 103 (64.0) | 0.70 |
| Modified SOFA*, median (IQR) | 7 (5–9) | 8 (6–10) | 6 (4–8) | <0.001 |
| Chronic liver disease, n (%) | 33 (10.3) | 28 (17.5) | 5 (3.1) | <0.001 |
| Immune suppression, n (%) | 59 (18.4) | 29 (18.1) | 30 (18.6) | 0.91 |
| Active neoplasm, n (%) | 19 (5.9) | 5 (3.1) | 14 (8.7) | 0.034 |
| ICU mortality, n (%) | 84 (26.2) | 50 (31.3) | 34 (21.2) | 0.050 |
| 30-d mortality, n (%) | 93 (29.0) | 57 (35.6) | 36 (22.4) | 0.023 |
Definition of abbreviations: AH50 = alternative complement pathway function; ARDS = acute respiratory distress syndrome; IQR = interquartile range; OSH = outside hospital; SOFA = sequential organ failure assessment score.
Odds ratio for AH50 ≥ median is 0.58 (95% confidence interval, 0.34–1.00; P = 0.050) for ICU mortality and 0.53 (95% confidence interval, 0.31–0.91; P = 0.023) for 30-day mortality. Odds ratios are adjusted for AH50 batch effect, presence of active neoplasm, sex, SOFA, and patient age.
*
Modified SOFA score calculated with neurologic score equal to 0; therefore, maximum score is 20.